Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen 510081, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Sensors (Basel). 2017 Jan 20;17(1):194. doi: 10.3390/s17010194.
Breath acetone serves as a biomarker for diabetes. This article reports 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF₄]), a type of room temperature ionic liquid (RTIL), as a selective sensing material for acetone. The RTIL sensing layer was coated on a quartz crystal microbalance (QCM) for detection. The sensing mechanism is based on a decrease in viscosity and density of the [bmim][BF₄] film due to the solubilization of acetone leading to a positive frequency shift in the QCM. Acetone was detected with a linear range from 7.05 to 750 ppmv. Sensitivity and limit of detection were found to be 3.49 Hz/ppmv and 5.0 ppmv, respectively. The [bmim][BF₄]-modified QCM sensor demonstrated anti-interference ability to commonly found volatile organic compounds in breath, e.g., isoprene, 1,2-pentadiene, -limonene, and -limonene. This technology is useful for applications in non-invasive early diabetic diagnosis.
呼吸丙酮可作为糖尿病的生物标志物。本文报道了 1-丁基-3-甲基咪唑四氟硼酸盐([bmim][BF₄])，一种室温离子液体(room temperature ionic liquid，RTIL)，可用作丙酮的选择性传感材料。RTIL 传感层涂覆在石英晶体微天平(quartz crystal microbalance，QCM)上进行检测。传感机制基于丙酮的溶解导致 [bmim][BF₄] 膜的粘度和密度降低，从而使 QCM 产生正频率偏移。丙酮的检测范围为 7.05 至 750 ppmv。检测的灵敏度和检出限分别为 3.49 Hz/ppmv 和 5.0 ppmv。[bmim][BF₄]修饰的 QCM 传感器对呼吸中常见的挥发性有机化合物，如异戊二烯、1,2-戊二烯、-柠檬烯和-柠檬烯，具有抗干扰能力。该技术可用于非侵入性早期糖尿病诊断等应用。
