柔软肉芝软珊瑚中的新型柳珊瑚烷类化合物——柔软肉芝醇A - I
Klyflaccicembranols A-I, New Cembranoids from the Soft Coral Klyxum flaccidum.
作者信息
Ahmed Atallah F, Tsai Chia-Ruei, Huang Chiung-Yao, Wang Sheng-Yang, Sheu Jyh-Horng
机构信息
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
出版信息
Mar Drugs. 2017 Jan 21;15(1):23. doi: 10.3390/md15010023.
New cembranoids klyflaccicembranols A-I (-), along with gibberosene D (), have been isolated from the organic extract of a Formosan soft coral . Their structures were established by extensive spectroscopic analyses, including 2D NMR spectroscopy, and spectral data comparison with related structures. The cytotoxicity of the isolated metabolites, as well as their nitric oxide (NO) inhibitory activity, were evaluated and reported. Metabolites , , , and were found to exhibit variable activities against a limited panel of cancer cell lines in a range of IC 16.5-49.4 μM. Among the tested cembranoids, compounds , , , and significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages at a dose of 50 μg/mL.
从台湾软珊瑚的有机提取物中分离出了新的西松烷类化合物克利弗拉西松醇A - I（-）以及吉贝罗烯D（）。通过广泛的光谱分析，包括二维核磁共振光谱，并与相关结构进行光谱数据比较，确定了它们的结构。对分离出的代谢产物的细胞毒性及其一氧化氮（NO）抑制活性进行了评估并报告。发现代谢产物、、、和对一组有限的癌细胞系表现出不同的活性，IC范围为16.5 - 49.4 μM。在所测试的西松烷类化合物中，化合物、、、和在50 μg/mL的剂量下显著抑制脂多糖（LPS）刺激的RAW264.7巨噬细胞中NO的产生。
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