Klymollins T-X，来自软珊瑚Klyxum molle的具有生物活性的基于海松二萜的二萜类化合物。

Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle.

作者信息

Chang Fang-Yu, Hsu Fang-Jung, Tai Chi-Jen, Wei Wen-Chi, Yang Ning-Sun, Sheu Jyh-Horng

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan.

出版信息

Mar Drugs. 2014 May 22;12(5):3060-71. doi: 10.3390/md12053060.

DOI:10.3390/md12053060

PMID:24857963

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4052331/

Abstract

Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.

摘要

从软珊瑚Klyxum molle中分离出了五种新的基于海葵二萜的化合物，即klymollins T-X（1-5），以及两种已知化合物（6和7）。通过广泛的光谱分析并与相关已知化合物进行比较，阐明了这些新代谢物的结构。发现化合物5对脂多糖刺激的RAW264.7巨噬细胞具有显著的体外抗炎活性。此外，化合物4和7对一组有限的人类癌细胞系表现出细胞毒性。