南海软珊瑚来源的新抗菌二萜

College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Mar Drugs. 2023 Jun 16;21(6):362. doi: 10.3390/md21060362.

Fifteen new diterpenoids, namely xishaklyanes A-O (-), along with three known related ones (-), were isolated from the soft coral collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds was elucidated by a combination of detailed spectroscopic analyses, chemical derivatization, quantum chemical calculations, and comparison with the reported data. The absolute configuration of compound was established by the modified Mosher's method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound showed the most effective activity with MIC of 0.225 μg/mL against .

从南海西沙群岛采集的软珊瑚中分离得到 15 个新的二萜类化合物，即 xishaklyanes A-O(-)，以及 3 个已知的相关化合物(-)。通过详细的光谱分析、化学衍生化、量子化学计算以及与报道数据的比较，确定了新化合物的立体化学。化合物的绝对构型首次通过改进的 Mosher 法确定。在生物测定中，这些化合物中的一些对鱼类病原菌表现出相当强的抗菌活性，化合物表现出最有效的活性，MIC 为 0.225μg/mL 对。