植物大麻素的分子靶点：一幅复杂的图景。
Molecular Targets of the Phytocannabinoids: A Complex Picture.
作者信息
Morales Paula, Hurst Dow P, Reggio Patricia H
机构信息
Chemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA.
出版信息
Prog Chem Org Nat Prod. 2017;103:103-131. doi: 10.1007/978-3-319-45541-9_4.
Abstract
For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis. For many years, it was assumed that the beneficial effects of the phytocannabinoids were mediated by the cannabinoid receptors, CB and CB. However, today we know that the picture is much more complex, with the same phytocannabinoid acting at multiple targets. This contribution focuses on the molecular pharmacology of the phytocannabinoids, including Δ-THC and CBD, from the prospective of the targets at which these important compounds act.
摘要
几个世纪以来，源自印度大麻（Cannabis sativa L.）的哈希什和大麻，因其药用及精神作用而被使用。这些作用与植物大麻素有关，植物大麻素是在印度大麻中发现的含氧C芳烃。迄今为止，已从大麻中分离出120多种植物大麻素。多年来，人们一直认为植物大麻素的有益作用是由大麻素受体CB1和CB2介导的。然而，如今我们知道情况要复杂得多，同一种植物大麻素会作用于多个靶点。本论文从这些重要化合物作用靶点的角度，聚焦于植物大麻素的分子药理学，包括Δ⁹-四氢大麻酚（Δ⁹-THC）和大麻二酚（CBD）。
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本文引用的文献
1
Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy.大麻二酚的人体代谢产物：关于其形成、生物活性及治疗相关性的综述
Cannabis Cannabinoid Res. 2016 Mar 1;1(1):90-101. doi: 10.1089/can.2015.0012. eCollection 2016.
2
Allosteric Modulators of the CB Cannabinoid Receptor: A Structural Update Review.CB大麻素受体的变构调节剂：结构更新综述
Cannabis Cannabinoid Res. 2016 Jan 1;1(1):22-30. doi: 10.1089/can.2015.0005. eCollection 2016.
3
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.纳米圆盘内的TRPV1结构揭示了配体和脂质的作用机制。
Nature. 2016 Jun 16;534(7607):347-51. doi: 10.1038/nature17964. Epub 2016 May 18.
4
An update on PPAR activation by cannabinoids.大麻素对过氧化物酶体增殖物激活受体（PPAR）激活作用的最新进展。
Br J Pharmacol. 2016 Jun;173(12):1899-910. doi: 10.1111/bph.13497. Epub 2016 May 19.
5
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Curr Opin Ophthalmol. 2016 Mar;27(2):146-50. doi: 10.1097/ICU.0000000000000242.
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Cochrane Database Syst Rev. 2016 Feb 2;2(2):CD007786. doi: 10.1002/14651858.CD007786.pub3.
7
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Br J Pharmacol. 2016 Mar;173(5):815-25. doi: 10.1111/bph.13368. Epub 2016 Feb 3.
9
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Br J Pharmacol. 2015 Oct;172(20):4790-805. doi: 10.1111/bph.13250. Epub 2015 Oct 13.
10
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