Office of Health Assessment and Translation, National Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709 USA.
Epidemiology Department, National Institute of Environmental Health Sciences, Chapel Hill, North Carolina, USA.
J Expo Sci Environ Epidemiol. 2017 Sep;27(5):458-464. doi: 10.1038/jes.2016.82. Epub 2017 Jan 25.
It is hypothesized that certain chemicals in personal care products may alter the risk of adverse health outcomes. The primary aim of this study was to use a data-centered approach to classify complex patterns of exposure to personal care products and to understand how these patterns vary according to use of exogenous hormone exposures, oral contraceptives (OCs) and post-menopausal hormone therapy (HT). The NIEHS Sister Study is a prospective cohort study of 50,884 US women. Limiting the sample to non-Hispanic blacks and whites (N=47,019), latent class analysis (LCA) was used to identify groups of individuals with similar patterns of personal care product use based on responses to 48 survey questions. Personal care products were categorized into three product types (beauty, hair, and skincare products) and separate latent classes were constructed for each type. Adjusted prevalence differences (PD) were calculated to estimate the association between exogenous hormone use, as measured by ever/never OC or HT use, and patterns of personal care product use. LCA reduced data dimensionality by grouping of individuals with similar patterns of personal care product use into mutually exclusive latent classes (three latent classes for beauty product use, three for hair, and four for skin care. There were strong differences in personal care usage by race, particularly for haircare products. For both blacks and whites, exogenous hormone exposures were associated with higher levels of product use, especially beauty and skincare products. Relative to individual product use questions, latent class variables capture complex patterns of personal care product usage. These patterns differed by race and were associated with ever OC and HT use. Future studies should consider personal care product exposures with other exogenous exposures when modeling health risks.
据推测，个人护理产品中的某些化学物质可能会改变不良健康结果的风险。本研究的主要目的是使用以数据为中心的方法对个人护理产品的暴露模式进行分类，并了解这些模式如何根据外源性激素暴露、口服避孕药（OC）和绝经后激素治疗（HT）的使用而变化。NIEHS 姐妹研究是一项针对 50884 名美国女性的前瞻性队列研究。将样本限制在非西班牙裔黑人和白人（N=47019）中，使用潜在类别分析（LCA）根据对 48 个调查问题的回答，识别具有相似个人护理产品使用模式的个体群体。个人护理产品分为三种产品类型（美容、头发和皮肤护理产品），并为每种类型分别构建单独的潜在类别。调整后的患病率差异（PD）用于估计外源性激素使用（通过使用 OC 或 HT 的情况进行衡量）与个人护理产品使用模式之间的关联。LCA 通过将具有相似个人护理产品使用模式的个体分组到互斥的潜在类别中（美容产品使用的三个潜在类别、头发的三个潜在类别和皮肤护理的四个潜在类别）来降低数据维度。种族之间个人护理产品的使用存在很大差异，尤其是在头发护理产品方面。对于黑人和白人来说，外源性激素暴露与更高水平的产品使用相关，尤其是美容和皮肤护理产品。与个别产品使用问题相比，潜在类别变量可以捕捉个人护理产品使用的复杂模式。这些模式因种族而异，与 OC 和 HT 的使用情况有关。未来的研究在建模健康风险时应考虑个人护理产品暴露与其他外源性暴露。
