化学美发产品的使用与表观遗传年龄之间的关联：姐妹研究的结果。
Associations between use of chemical hair products and epigenetic age: Findings from the Sister Study.
作者信息
Chang Che-Jung, O'Brien Katie M, Kresovich Jacob K, Nwanaji-Enwerem Jamaji C, Xu Zongli, Gaston Symielle A, Jackson Chandra L, Sandler Dale P, Taylor Jack A, White Alexandra J
机构信息
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Departments of Cancer Epidemiology and Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
出版信息
Environ Epidemiol. 2024 May 17;8(3):e311. doi: 10.1097/EE9.0000000000000311. eCollection 2024 Jun.
BACKGROUND
Hair products may be a source of harmful chemicals and have been linked to age-related health outcomes. We investigated whether the use of hair products is related to epigenetic age in a sample of Black (both Hispanic and non-Hispanic) and non-Hispanic White women.
METHODS
In a subset of 4358 participants aged 35-74 years from the Sister Study, we estimated cross-sectional associations between self-reported use of four chemical hair products (permanent dye, semipermanent dye, straighteners/relaxers, and hair permanents/body waves) in the year before enrollment (2003-2009) and three DNA methylation-based measures of epigenetic age (DunedinPACE, GrimAge age acceleration [GrimAgeAccel], and PhenoAge age acceleration [PhenoAgeAccel]) using survey-weighted multivariable linear regressions. Associations were estimated both overall and by self-identified race and ethnicity, adjusting for chronological age, socioeconomic and lifestyle factors, body mass index, menopausal status, and DNA methylation platform.
RESULTS
Associations between the use of hair products and the three epigenetic age measures were largely null. Use of hair permanents/body waves was modestly associated with higher DunedinPACE among all participants ( = 0.010; 95% confidence interval [CI] = 0.001, 0.019) and with lower PhenoAgeAccel among Black women ( = -1.53; 95% CI = -2.84, -0.21).
CONCLUSION
In this US-based study, we found little evidence of associations between chemical hair product use and epigenetic age in Black and non-Hispanic White women. Observed associations were modest and largely not supported by dose-response relationships or were inconsistent across epigenetic age measures. Previously observed associations between chemical hair product use and aging-related health outcomes may not be explained by the biological aging pathways captured by DunedinPACE, GrimAgeAccel, or PhenoAgeAccel. Alternative biological pathways are worth investigating in racially diverse samples.
背景
美发产品可能是有害化学物质的来源，并且与年龄相关的健康结果有关。我们在黑人（包括西班牙裔和非西班牙裔）和非西班牙裔白人女性样本中调查了美发产品的使用是否与表观遗传年龄有关。
方法
在“姐妹研究”中年龄在35 - 74岁的4358名参与者的子集中，我们使用调查加权多变量线性回归估计了在入组前一年（2003 - 2009年）自我报告使用四种化学美发产品（永久性染发剂、半永久性染发剂、直发剂/松弛剂和烫发/身体波浪）与三种基于DNA甲基化的表观遗传年龄测量指标（达尼丁PACE、GrimAge年龄加速[GrimAgeAccel]和PhenoAge年龄加速[PhenoAgeAccel]）之间的横断面关联。总体以及按自我认定的种族和族裔分别估计关联，并对实足年龄、社会经济和生活方式因素、体重指数、绝经状态和DNA甲基化平台进行了调整。
结果
美发产品的使用与三种表观遗传年龄测量指标之间的关联大多为零。在所有参与者中，使用烫发/身体波浪与较高的达尼丁PACE适度相关（β = 0.010；95%置信区间[CI] = 0.001，0.019），在黑人女性中与较低的PhenoAgeAccel相关（β = -1.53；95% CI = -2.84，-0.21）。
结论
在这项基于美国的研究中，我们几乎没有发现黑人及非西班牙裔白人女性使用化学美发产品与表观遗传年龄之间存在关联的证据。观察到的关联程度较小，并且在很大程度上没有得到剂量反应关系的支持，或者在不同的表观遗传年龄测量指标之间不一致。先前观察到的化学美发产品使用与衰老相关健康结果之间的关联可能无法通过达尼丁PACE、GrimAgeAccel或PhenoAgeAccel所捕捉的生物衰老途径来解释。在种族多样化的样本中，值得研究其他生物途径。
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