Bergmann M M, Hernandez V, Bernigau W, Boeing H, Chan S S M, Luben R, Khaw K-T, van Schaik F, Oldenburg B, Bueno-de-Mesquita B, Overvad K, Palli D, Masala G, Carbonnel F, Boutron-Ruault M-C, Olsen A, Tjonneland A, Kaaks R, Katzke V, Riboli E, Hart A R
Department of Gastroenterology, German Institute of Human Nutrition, Potsdam, Germany.
Department of Gastroenterology, Instituto de Investigación Biomédica, Estrutura Organizativa de Xestión Integrada de Vigo, Vigo, Spain.
Eur J Clin Nutr. 2017 Apr;71(4):512-518. doi: 10.1038/ejcn.2016.271. Epub 2017 Jan 25.
BACKGROUND/OBJECTIVES: The role of long-term alcohol consumption for the risk of developing ulcerative colitis (UC) and Crohn's disease (CD) is unclear. For the first time, to prospectively assess the role of pre-disease alcohol consumption on the risk of developing UC or CD.
SUBJECTS/METHODS: Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC-IBD), incident UC and CD cases and matched controls where included. At recruitment, participants completed validated food frequency and lifestyle questionnaires. Alcohol consumption was classified as either: non-use, former, light (⩽0.5 and 1 drink per week), below the recommended limits (BRL) (⩽1 and 2 drinks per day), moderate (⩽2.5 and 5 drinks per day), or heavy use (>2.5 and >5 drinks per day) for women and men, respectively; and was expressed as consumption at enrolment and during lifetime. Conditional logistic regression was applied adjusting for smoking and education, taking light users as the reference.
Out of 262 451 participants in six countries, 198 UC incident cases/792 controls and 84 CD cases/336 controls were included. At enrolment, 8%/27%/32%/23%/11% UC cases and 7%/29%/40%/19%/5% CD cases were: non-users, light, BRL, moderate and heavy users, respectively. The corresponding figures for lifetime non-use, former, light, BRL, moderate and heavy use were: 3%/5%/23%/44%/19%/6% and 5%/2%/25%/44%/23%/1% for UC and CD cases, respectively. There were no associations between any categories of alcohol consumption and risk of UC or CD in the unadjusted and adjusted odds ratios.
There was no evidence of associations between alcohol use and the odds of developing either UC or CD.
背景/目的：长期饮酒对溃疡性结肠炎（UC）和克罗恩病（CD）发病风险的作用尚不清楚。首次前瞻性评估疾病前饮酒对患UC或CD风险的作用。
受试者/方法：纳入欧洲癌症与营养前瞻性调查（EPIC-IBD）中的新发UC和CD病例及匹配对照。招募时，参与者完成经过验证的食物频率和生活方式问卷。饮酒情况分为：不饮酒、既往饮酒、轻度（每周≤0.5杯和1杯）、低于推荐限量（BRL）（每天≤1杯和2杯）、中度（每天≤2.5杯和5杯）或重度饮酒（女性和男性分别>2.5杯和>5杯）；并表示为入组时和一生中的饮酒量。应用条件逻辑回归，对吸烟和教育程度进行校正，以轻度饮酒者作为对照。
六个国家的262451名参与者中，包括198例新发UC病例/792例对照和84例CD病例/336例对照。入组时，UC病例的8%/27%/32%/23%/11%和CD病例的7%/29%/40%/19%/5%分别为：不饮酒者、轻度饮酒者、BRL饮酒者、中度饮酒者和重度饮酒者。UC和CD病例一生中不饮酒、既往饮酒、轻度饮酒、BRL饮酒、中度饮酒和重度饮酒的相应比例分别为：3%/5%/23%/44%/19%/6%和5%/2%/25%/44%/23%/1%。在未校正和校正的优势比中，任何饮酒类别与UC或CD风险之间均无关联。
没有证据表明饮酒与患UC或CD的几率之间存在关联。
