Singapore National Eye Centre, Singapore.
Singapore Eye Research Institute, Singapore.
Sci Rep. 2017 Jan 25;7:41386. doi: 10.1038/srep41386.
To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and polypoidal choroidal vasculoapthy (PCV) subtypes. We recruited 456 cases and 1,824 controls matched for age, gender and ethnicity. Data on systemic and ocular risk factors were collected on questionnaires. In a subgroup of subjects, we included genetic data on four AMD-associated single nucleotide polymorphisms (SNPs). Risk factors for nAMD and subtypes were analyzed. Systemic risk factors for nAMD included older age, male gender, higher BMI and higher HDL-cholesterol. Ocular risk factors included pseudophakic and shorter axial length. Risk factors common to both typical AMD and PCV subtypes included age, BMI and HDL-cholesterol. Shorter axial length was only associated with PCV, while male gender and pseudophakia were only associated with typical AMD. In the subgroup with genotype data, ARMS2 rs10490924 and CFH rs800292 were associated with nAMD. None of the risk factors were significantly different between PCV and typical AMD. Systemic, ocular and genetic risk factors were largely similar for typical AMD and PCV subtypes in this Asian population based in Singapore.
为了在一个大型亚洲患者队列中检查新生血管性年龄相关性黄斑变性（nAMD）的系统性、眼部和遗传风险因素之间的关联，并进一步比较具有典型 AMD 和息肉状脉络膜血管病变（PCV）亚型的风险因素，我们招募了 456 例病例和 1824 例年龄、性别和种族匹配的对照。我们通过问卷收集了关于系统性和眼部风险因素的数据。在一组亚组受试者中，我们纳入了四个与 AMD 相关的单核苷酸多态性（SNP）的遗传数据。分析了 nAMD 和亚型的风险因素。nAMD 的系统性风险因素包括年龄较大、男性、较高的 BMI 和较高的 HDL-胆固醇。眼部风险因素包括假晶状体和较短的眼轴。与典型 AMD 和 PCV 亚型均相关的风险因素包括年龄、BMI 和 HDL-胆固醇。较短的眼轴仅与 PCV 相关，而男性和假晶状体仅与典型 AMD 相关。在具有基因型数据的亚组中，ARMS2 rs10490924 和 CFH rs800292 与 nAMD 相关。在新加坡的这个亚洲人群中，PCV 和典型 AMD 之间的风险因素没有显著差异。在这个基于新加坡的亚洲人群中，典型 AMD 和 PCV 亚型的系统性、眼部和遗传风险因素在很大程度上是相似的。
