用于双模态光学成像、可控药物释放和协同治疗的壳聚糖门控磁响应纳米载体
Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy.
作者信息
Wang Hui, Mu Qingxin, Revia Richard, Wang Kui, Zhou Xuezhe, Pauzauskie Peter J, Zhou Shuiqin, Zhang Miqin
机构信息
Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.
出版信息
Adv Healthc Mater. 2017 Mar;6(6). doi: 10.1002/adhm.201601080. Epub 2017 Jan 25.
Abstract
A dual-layer shell hollow nanostructure as drug carrier that provides instant on/off function for drug release and contrast enhancement for multimodal imaging is reported. The on-demand drug release is triggered by irradiation of an external magnetic field. The nanocarrier also demonstrates a high drug loading capacity and synergistic magnetic-thermal and chemotherapy.
摘要
报道了一种双层壳中空纳米结构作为药物载体，其为药物释放提供即时开启/关闭功能，并为多模态成像增强对比度。按需药物释放由外部磁场照射触发。该纳米载体还表现出高载药能力以及磁热和化疗协同作用。
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