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1
Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up.口腔和胃肠道黏膜损伤的管理：ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2015 Sep;26 Suppl 5:v139-51. doi: 10.1093/annonc/mdv202. Epub 2015 Jul 4.
2
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.MASCC/ISOO 临床实践指南：癌症治疗相关黏膜炎的管理。
Cancer. 2014 May 15;120(10):1453-61. doi: 10.1002/cncr.28592. Epub 2014 Feb 25.
3
Effect of topical chamomile on immunohistochemical levels of IL-1β and TNF-α in 5-fluorouracil-induced oral mucositis in hamsters.香芹对 5-氟尿嘧啶诱导的仓鼠口腔黏膜炎中 IL-1β 和 TNF-α 免疫组化水平的影响。
Cancer Chemother Pharmacol. 2013 Feb;71(2):293-9. doi: 10.1007/s00280-012-2013-9. Epub 2012 Oct 25.
4
Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke.肿瘤坏死因子-α（TNF-α）基因启动子多态性、循环 TNF-α水平与缺血性脑卒中的心血管危险因素。
J Neuroinflammation. 2012 Oct 10;9:235. doi: 10.1186/1742-2094-9-235.
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Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas.前瞻性评估常规化疗引起的实体瘤和恶性淋巴瘤口腔黏膜炎的发生率和严重程度。
Support Care Cancer. 2012 Sep;20(9):2053-9. doi: 10.1007/s00520-011-1314-6. Epub 2011 Nov 25.
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A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).一项比较术后顺铂联合氟尿嘧啶辅助化疗与术前化疗治疗局部晚期食管鳞状细胞癌（JCOG9907）的随机临床试验。
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8
A phase II trial of chemoradiotherapy for stage I esophageal squamous cell carcinoma: Japan Clinical Oncology Group Study (JCOG9708).I期食管鳞状细胞癌同步放化疗的II期试验：日本临床肿瘤学组研究（JCOG9708）
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J Clin Oncol. 2009 Jan 1;27(1):127-45. doi: 10.1200/JCO.2008.17.2627. Epub 2008 Nov 17.
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Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs.给予黏液毒性药物后血清中NFκB和促炎细胞因子的水平。
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肿瘤坏死因子-α基因多态性与食管癌患者化疗所致口腔黏膜炎的相关性

Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer.

作者信息

Sakamoto Kazuhiko, Takeda Shigeru, Kanekiyo Shinsuke, Nishiyama Mitsuo, Kitahara Masahiro, Ueno Tomio, Yamamoto Shigeru, Yoshino Shigefumi, Hazama Shoichi, Okayama Naoko, Nagano Hiroaki

机构信息

Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.

Oncology Center, Yamaguchi University Hospital, Ube, Yamaguchi 755-8505, Japan.

出版信息

Mol Clin Oncol. 2017 Jan;6(1):125-129. doi: 10.3892/mco.2016.1081. Epub 2016 Nov 14.

DOI:10.3892/mco.2016.1081
PMID:28123745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5244836/
Abstract

The purpose of this study was to evaluate the association between tumor necrosis factor (TNF)-α polymorphisms and oral mucositis (OM) from 5-fluorouracil (5-FU) plus cisplatin (CDDP) chemotherapy for esophageal cancer. The rs1799964 polymorphism of TNF-α was genotyped using the tetra-primer amplification refractory mutation system polymerase chain reaction. The experimental group comprised 64 patients who received chemotherapy for esophageal cancer between 1997 and 2004; a total of 106 patients between 2005 and 2013 were investigated as the validation group. Univariate analysis of the experimental group revealed that the TT genotype of TNF-α rs1799964 was significantly higher in patients with grade 1-4 OM compared with the TC/CC genotypes [univariate odds ratio (OR)=4.0; P=0.029]. Similarly, univariate analysis of the validation group revealed that the percentage of the TT genotype was significantly higher in patients with grade 1-4 OM compared with the TC/CC genotypes (OR=2.8; P=0.043). This difference in risk was replicated in the validation cohort. Thus, the TT genotype of TNF-α rs1799964 may be a predictor of chemotherapy-induced OM in patients with esophageal cancer.

摘要

本研究旨在评估肿瘤坏死因子（TNF）-α基因多态性与食管癌患者接受5-氟尿嘧啶（5-FU）联合顺铂（CDDP）化疗所致口腔黏膜炎（OM）之间的关联。采用四引物扩增阻滞突变系统聚合酶链反应对TNF-α的rs1799964基因多态性进行基因分型。实验组包括1997年至2004年间接受食管癌化疗的64例患者；2005年至2013年间共106例患者作为验证组进行调查。实验组的单因素分析显示，与TC/CC基因型相比，1-4级OM患者中TNF-α rs1799964的TT基因型显著更高[单因素比值比（OR）=4.0；P=0.029]。同样，验证组的单因素分析显示，与TC/CC基因型相比，1-4级OM患者中TT基因型的百分比显著更高（OR=2.8；P=0.043）。这种风险差异在验证队列中得到了重复。因此，TNF-α rs1799964的TT基因型可能是食管癌患者化疗所致OM的一个预测指标。