van Gils T, Brand H S, de Boer N K H, Mulder C J J, Bouma G
Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands.
Departments of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Br Dent J. 2017 Jan 27;222(2):126-129. doi: 10.1038/sj.bdj.2017.80.
Coeliac disease is a chronic autoimmune-mediated enteropathy, caused by exposure to dietary gluten in genetically predisposed individuals that affects approximately 0.5-1% of the western population. Despite increased awareness of the disease, the majority of patients still remain undiagnosed. Disease frequently manifests in early childhood, but a significant proportion of patients are nowadays diagnosed above the age of 50. Timely diagnosis is important in order to start a gluten-free diet and prevent complications. Symptoms of coeliac disease vary widely and are certainly not restricted to the intestine. They may include, among others, dental and oral manifestations. Most of them are nonspecific but symmetric enamel defects are very specific to coeliac disease. It is important to recognise this relationship since it may help to identify unrecognised patients.
乳糜泻是一种慢性自身免疫介导的肠病，由遗传易感性个体摄入膳食麸质引起，影响约0.5-1%的西方人群。尽管对该疾病的认识有所提高，但大多数患者仍未被诊断出来。该疾病常在儿童早期出现，但如今相当一部分患者在50岁以上才被诊断出来。及时诊断对于开始无麸质饮食和预防并发症很重要。乳糜泻的症状差异很大，当然不限于肠道。其中可能包括牙齿和口腔表现。大多数表现是非特异性的，但对称性釉质缺陷对乳糜泻非常具有特异性。认识到这种关系很重要，因为它可能有助于识别未被诊断的患者。
