Dental Department, Jubail General Hospital, Ministry of Health, P.O. Box 1275, Al Jubail, 31951, Saudi Arabia.
Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
BMC Oral Health. 2021 Dec 29;21(1):669. doi: 10.1186/s12903-021-01976-4.
Celiac disease (CD) is an immune-mediated enteropathy. CD may also involve complications with the oral cavity, which can result in various dental and oral pathologies. There are currently a limited number of studies on the oral manifestation of CD. This study aims to compare the oral manifestations of children with CD against healthy controls in Saudi Arabia.
This study includes 208 children aged 6-14 years, distributed equally into CD patients and healthy controls. A parent completed and validated the interview questionnaire, which included the child's personal information and medical history. A dental examination was undertaken to measure possible recurrent aphthous stomatitis (RAS), dental enamel defects (DEDs), dental caries experience, and dental malocclusion. Data were analyzed using descriptive statistics and bivariate and multivariate analysis.
Two hundred and eight participants were included (104 CD patients and 104 controls). The mean age for CD patients was 10.67 ± 2.39 years and 10.69 ± 2.36 for the healthy controls. CD children had more RAS than controls (42.3% vs. 15.4%, P < 0.001) (OR = 4.03, 95% CI = 2.09-7.81) and more DEDs than healthy controls (70.2% vs. 34.6%, P < 0.001) (OR = 4.45, 95% CI = 2.48-7.97). No significant difference was found in the frequency of malocclusion between cases and controls.
Saudi Arabian children with CD had a greater number of clinical findings of RAS and DEDs than healthy controls. Pediatric dentists should consider the possibility of CD in child patients presenting with RAS or DEDs.
乳糜泻（CD）是一种免疫介导的肠病。CD 也可能涉及口腔并发症，从而导致各种牙科和口腔病理学。目前，关于 CD 的口腔表现的研究数量有限。本研究旨在比较沙特阿拉伯儿童 CD 患者与健康对照组的口腔表现。
本研究纳入了 208 名 6-14 岁的儿童，平均分为 CD 患者和健康对照组。由家长完成并验证了访谈问卷，其中包括儿童的个人信息和病史。进行了口腔检查以测量可能的复发性阿弗他口炎（RAS）、牙釉质缺陷（DED）、龋齿经历和牙齿错位。使用描述性统计和双变量及多变量分析对数据进行分析。
共纳入 208 名参与者（104 名 CD 患者和 104 名对照组）。CD 患者的平均年龄为 10.67±2.39 岁，健康对照组为 10.69±2.36 岁。CD 患儿的 RAS 多于对照组（42.3%比 15.4%，P<0.001）（OR=4.03，95%CI=2.09-7.81），DED 多于健康对照组（70.2%比 34.6%，P<0.001）（OR=4.45，95%CI=2.48-7.97）。病例组和对照组的错畸形频率无显著差异。
沙特阿拉伯 CD 儿童的 RAS 和 DED 临床发现多于健康对照组。儿科牙医应考虑在出现 RAS 或 DED 的儿童患者中存在 CD 的可能性。
