Kurt A, Kurt E E, Kilic R, Oktem C, Tuncay F, Erdem H R
Bratisl Lek Listy. 2017;118(1):23-27. doi: 10.4149/BLL_2017_005.
Aim of the study was to evaluate the choroidal thickness (CT) in patients with RA and detect the relation with disease activity and joint damage in patients with rheumatoid arthritisBACKGROUND: Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with various extra-articular organ manifestations including ocular manifestationsMATERIALS AND METHODS: We included 59 eyes of 59 patients with RA and 59 eyes of 59 controls without RA in the study. Subfoveal and perifoveal CT were measured using enhanced depth imaging optic coherence tomography. Disease activity score 28 (DAS 28) and Larsen score were calculated for each patient with RA and compared with measurements of CT.
CT was statistically thinner in patients with RA than controls, at subfoveal CT (p = 0.008), at 500 μm temporal to the fovea (p = 0.004), at 1000 μm temporal to the fovea (p = 0.010), at 1500 μm temporal to the fovea (p = 0.005), at 500 μm nasal to the fovea (p = 0.035). Additionally there was no correlation measurements of CT with disease activity and joint damage.
Subfoveal and perifoveal CT was significantly thinner in patients with RA than in healthy controls but there was no correlation detected between CT measurements and DAS 28 or Larsen scores (Tab. 5, Ref. 33).
本研究旨在评估类风湿关节炎（RA）患者的脉络膜厚度（CT），并检测其与类风湿关节炎患者疾病活动度和关节损伤的关系。
类风湿关节炎（RA）是一种全身性炎症性疾病，与包括眼部表现在内的各种关节外器官表现相关。
本研究纳入了59例RA患者的59只眼和59例非RA对照者的59只眼。使用增强深度成像光学相干断层扫描测量黄斑中心凹下和黄斑中心凹周围的CT。计算每位RA患者的疾病活动评分28（DAS 28）和 Larsen评分，并与CT测量值进行比较。
RA患者的CT在统计学上比对照组更薄，在黄斑中心凹下CT（p = 0.008）、在黄斑中心凹颞侧500μm处（p = 0.004）、在黄斑中心凹颞侧1000μm处（p = 0.010）、在黄斑中心凹颞侧1500μm处（p = 0.005）、在黄斑中心凹鼻侧500μm处（p = 0.035）。此外，CT测量值与疾病活动度和关节损伤之间没有相关性。
RA患者的黄斑中心凹下和黄斑中心凹周围CT明显比健康对照者薄，但CT测量值与DAS 28或Larsen评分之间未检测到相关性（表5，参考文献33）。
