Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Laboratory of Gastrointestinal Onco-Pathology, Cancer Institute &General Surgery Institute, The First Hospital of China Medical University, Shenyang 110001, China.
Sci Rep. 2017 Jan 27;7:41298. doi: 10.1038/srep41298.
The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the CAR as a prognostic indicator in solid cancers. In this meta-analysis, we collected data from 10 studies that examined the association between serum CAR and overall survival in patients with cancer. This meta-analysis included 4592 tumor patients. The eligible studies were found through the PubMed and Web of Science databases updated on 6 Oct 2016. The pooled hazard ratio (2.01, 95% CI: 1.58-2.56, p < 0.001) indicated that high CAR yielded worse survival in different cancers. Subgroup analyses showed a significant association between CAR and prognosis, regardless of the cutoff value, cutoff value selection, treatment method, country, sample size, stage and cancer type. This meta-analysis suggests that CAR may be a potential prognostic marker in solid cancers. However, further large prospective studies should be conducted to explore the critical role of CAR in survival of cancer patients.
C-反应蛋白/白蛋白比值（CAR）在多种癌症中具有重要的预后作用。我们旨在全面探讨 CAR 作为固体癌症预后指标的潜在作用。在这项荟萃分析中，我们从 10 项研究中收集了数据，这些研究检查了血清 CAR 与癌症患者总生存率之间的关系。这项荟萃分析包括 4592 名肿瘤患者。通过 PubMed 和 Web of Science 数据库进行了检索，这些数据库的更新日期为 2016 年 10 月 6 日。合并的风险比（2.01，95%CI：1.58-2.56，p<0.001）表明，CAR 水平高与不同癌症的生存率降低相关。亚组分析表明，无论截值、截值选择、治疗方法、国家、样本量、分期和癌症类型如何，CAR 与预后均存在显著相关性。这项荟萃分析表明，CAR 可能是固体癌症的一种潜在预后标志物。然而，应进行进一步的大型前瞻性研究，以探讨 CAR 在癌症患者生存中的关键作用。
