C-反应蛋白/白蛋白比值对鼻咽癌的预后价值：一项荟萃分析。
The prognostic value of C-reactive protein/albumin ratio in nasopharyngeal carcinoma: a meta-analysis.
机构信息
Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou 450052, Henan, China.
Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou 450052, Henan, China
出版信息
Biosci Rep. 2018 Nov 13;38(6). doi: 10.1042/BSR20180686. Print 2018 Dec 21.
The C-reactive protein/albumin ratio (CRP/Alb ratio) has been reported to have promising prognostic value in several cancers. The current meta-analysis was conducted to better define the prognostic value of CRP/Alb ratio in patients with nasopharyngeal carcinoma (NPC). The Web of Science, Embase, Cochrane Library databases, and PubMed were searched up to 25 February 2018 for the information on CRP/Alb ratio and outcomes of NPC. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) were used to evaluate the association between CRP/Alb ratio and survival outcomes in NPC. A total of five studies with 5533 patients with NPC were included. Pooled results showed that high CRP/Alb ratio was associated with poor overall survival (OS) (HR = 1.51, 95% CI: 1.30-1.75, <0.001) and poor distant metastasis-free survival (DMFS) (HR = 1.23, 95% CI: 1.07-1.43, =0.005). Subgroup analyses showed that patients with higher CRP/Alb ratio have worse OS in NPC. In conclusion, elevated CRP/Alb ratio was associated with worse prognosis in patients with NPC.
C-反应蛋白/白蛋白比值（CRP/Alb 比值）已被报道在多种癌症中具有有前途的预后价值。本荟萃分析旨在更好地定义 CRP/Alb 比值在鼻咽癌（NPC）患者中的预后价值。截至 2018 年 2 月 25 日，我们在 Web of Science、Embase、Cochrane Library 数据库和 PubMed 上搜索了有关 CRP/Alb 比值和 NPC 结局的信息。使用合并风险比（HRs）和相应的 95％置信区间（95％CI）来评估 CRP/Alb 比值与 NPC 生存结局之间的关联。共有五项研究纳入了 5533 例 NPC 患者。合并结果表明，高 CRP/Alb 比值与较差的总生存（OS）（HR = 1.51，95％CI：1.30-1.75，<0.001）和较差的无远处转移生存（DMFS）（HR = 1.23，95％CI：1.07-1.43，=0.005）相关。亚组分析表明，CRP/Alb 比值较高的患者在 NPC 中 OS 更差。总之，升高的 CRP/Alb 比值与 NPC 患者的预后较差相关。
Zotero 插件