School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China.
Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China.
Dalton Trans. 2017 Feb 14;46(7):2204-2213. doi: 10.1039/c6dt04308a.
In this study, a multifunctional nano-drug (PTX-loaded Cys-FeO/CuS@BSA nanocomposite), which performs well in hydrophobic drug delivery, magnetic resonance imaging (MRI) and chemo-photothermal combination therapy, has been successfully synthesized via a facile method with several biocompatible agents. The characterization verified that our as-obtained nanocarrier has a preferable average diameter of about 300 nm for cancer therapy, shows a great MRI ability and magnetism performance, and exhibits a favorable in vitro and in vivo photothermal therapeutic efficacy by introducing CuS, and the sustained release of chemotherapeutics could be controlled by pH value and near-infrared laser irradiation has further enhanced the therapeutic performance. Overall, the excellent synergistic effect to inhibit tumor growth effectively realized via imaging-guided combinational chemo-photothermal therapy in the present work, highlights the promise of conquering the limitations of tumor treatments.
在这项研究中，我们通过一种简便的方法，使用几种生物相容性试剂成功合成了一种多功能纳米药物（载紫杉醇的 Cys-FeO/CuS@BSA 纳米复合材料），该纳米药物在疏水性药物传递、磁共振成像（MRI）和化疗-光热联合治疗方面表现出色。通过对其进行的特性验证表明，我们所获得的纳米载体具有约 300nm 的较好平均直径，有利于癌症治疗，表现出很强的 MRI 能力和磁性性能，通过引入 CuS，表现出良好的体外和体内光热治疗效果，并且可以通过 pH 值和近红外激光照射控制化疗药物的持续释放，进一步增强了治疗效果。总的来说，本工作通过成像引导的联合化疗-光热治疗实现了对肿瘤生长的有效抑制，这突出了克服肿瘤治疗局限性的潜力。
