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载双药金纳米棒囊泡的智能纳米平台用于序贯药物释放和增强化疗-热疗效应的癌症治疗。

Smart nanoplatform for sequential drug release and enhanced chemo-thermal effect of dual drug loaded gold nanorod vesicles for cancer therapy.

机构信息

Department of Pharmacy, Nanfang Hospital, School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China.

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

出版信息

J Nanobiotechnology. 2019 Mar 27;17(1):44. doi: 10.1186/s12951-019-0473-3.

DOI:10.1186/s12951-019-0473-3
PMID:30917812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6437988/
Abstract

BACKGROUND

The combination of multiple chemotherapeutics has been used in the clinic for enhanced cancer chemotherapy, however, frequent relapse, chemo-resistance and side effects remains therapeutic hurdles. Thus, the development of co-delivery system with enhanced targeting and synergistic different modal treatments has been proposed as promising strategies for intensive improvement of the therapeutic outcomes.

RESULTS

We fabricated a nanocarrier based on gold nanorods (Au NRs), cRGD peptide-modified and multi-stimuli-responsive paclitaxel (PTX) and curcumin (CUR) release for synergistic anticancer effect and chemo-photothermal therapy (PTX/CUR/Au NRs@cRGD). The specific banding of cRGD to αvβ3 integrin receptor on the tumor cell surfaces facilitated the endocytosis of PTX/CUR/Au NRs@cRGD, and the near-infrared ray (NIR) further enhanced the drug release and chemotherapeutical efficiency. Compared to single drug, single model treatment or undecorated-PTX/CUR/Au NRs, the PTX/CUR/Au NRs@cRGD with a mild NIR showed significantly enhanced apoptosis and S phase arrest in three cancer cell lines in vitro, and improved drug accumulation in tumor sites as well as tumor growth inhibition in vivo.

CONCLUSIONS

The tumor targeted chemo-photothermal therapy with the synergistic effect of dual drugs provided a versatile strategy for precise cancer therapy.

摘要

背景

临床上已将多种化疗药物联合使用，以增强癌症化疗效果，但仍存在频繁复发、化疗耐药和副作用等治疗障碍。因此，开发具有增强靶向性和协同不同模式治疗作用的共递药系统已被提出作为提高治疗效果的有前途的策略。

结果

我们构建了一种基于金纳米棒（Au NRs）、cRGD 肽修饰和多刺激响应性紫杉醇（PTX）和姜黄素（CUR）释放的纳米载体，用于协同抗癌作用和化疗-光热治疗（PTX/CUR/Au NRs@cRGD）。cRGD 与肿瘤细胞表面 αvβ3 整合素受体的特异性结合促进了 PTX/CUR/Au NRs@cRGD 的内吞作用，近红外光（NIR）进一步增强了药物释放和化疗效率。与单药、单模式治疗或未修饰的 PTX/CUR/Au NRs 相比，温和 NIR 照射下的 PTX/CUR/Au NRs@cRGD 在体外三种癌细胞系中表现出明显增强的细胞凋亡和 S 期阻滞，以及肿瘤部位药物积累的改善和体内肿瘤生长的抑制。

结论

具有双重药物协同作用的肿瘤靶向化疗-光热治疗为精确癌症治疗提供了一种多功能策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/e221cba7451d/12951_2019_473_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/9193b86f3f45/12951_2019_473_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/79deccd4e01b/12951_2019_473_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/f7d4af0714e9/12951_2019_473_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/aa73c5e513c7/12951_2019_473_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/1b7e25dcfcbb/12951_2019_473_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/2d297ae91cd9/12951_2019_473_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/dce34a8d57f2/12951_2019_473_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/e221cba7451d/12951_2019_473_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/9193b86f3f45/12951_2019_473_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/79deccd4e01b/12951_2019_473_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/f7d4af0714e9/12951_2019_473_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/aa73c5e513c7/12951_2019_473_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/1b7e25dcfcbb/12951_2019_473_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/2d297ae91cd9/12951_2019_473_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/dce34a8d57f2/12951_2019_473_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd4/6437988/e221cba7451d/12951_2019_473_Fig8_HTML.jpg

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