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心房颤动的风险分层模型。

Risk Stratification Models in Atrial Fibrillation.

机构信息

University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom.

Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark.

出版信息

Semin Thromb Hemost. 2017 Jul;43(5):505-513. doi: 10.1055/s-0036-1597285. Epub 2017 Jan 27.

DOI:10.1055/s-0036-1597285
PMID:28129663
Abstract

Atrial fibrillation (AF) is associated with an increased risk of stroke compared with the general population. AF-related stroke confers a higher mortality and morbidity risk, and thus, early detection and assessment for the initiation of effective stroke prevention with oral anticoagulation are crucial. Simple and practical risk assessment tools are essential to facilitate stroke and bleeding risk assessment in busy clinics and wards to aid decision making. At present, the CHADSVASc score is recommended by guidelines as the most simple and practical method of assessing stroke risk in AF patients. Alongside this, the use of the HAS-BLED score aims to identify patients at high risk of bleeding for more regular review and follow-up, and draws attention to potentially reversible bleeding risk factors. The aim of this review article is to summarize the current risk scores available for both stroke and bleeding in AF patients, and the recommendations for their use.

摘要

心房颤动(AF)与普通人群相比,发生中风的风险增加。与 AF 相关的中风会带来更高的死亡率和发病率风险,因此,早期发现和评估,以启动有效的抗凝治疗预防中风至关重要。简单实用的风险评估工具对于在繁忙的诊所和病房中进行中风和出血风险评估,以辅助决策制定非常重要。目前,指南推荐 CHADSVASc 评分作为评估 AF 患者中风风险的最简单实用的方法。除此之外,使用 HAS-BLED 评分旨在识别出血风险较高的患者,以便更频繁地进行复查和随访,并注意潜在的可逆转出血风险因素。本文旨在总结目前 AF 患者中风和出血风险的评分,并对其应用提出建议。

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Risk Stratification Models in Atrial Fibrillation.心房颤动的风险分层模型。
Semin Thromb Hemost. 2017 Jul;43(5):505-513. doi: 10.1055/s-0036-1597285. Epub 2017 Jan 27.
2
Recent advances in the understanding and management of atrial fibrillation: a focus on stroke prevention.心房颤动的认识与管理的最新进展:聚焦于卒中预防
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3
Comparison of HAS-BLED and HAS-BED Versus CHADS and CHADSVASC Stroke and Bleeding Scores in Patients With Atrial Fibrillation.心房颤动患者中HAS - BLED和HAS - BED与CHADS和CHADSVASC卒中及出血评分的比较
Am J Cardiol. 2017 Apr 1;119(7):1012-1016. doi: 10.1016/j.amjcard.2016.12.007. Epub 2017 Jan 26.
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Relation of the HAS-BLED bleeding risk score to major bleeding, cardiovascular events, and mortality in anticoagulated patients with atrial fibrillation.HAS-BLED 出血风险评分与抗凝治疗的心房颤动患者的大出血、心血管事件和死亡率的关系。
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The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial fibrillation.在接受抗凝治疗的房颤患者中,HAS-BLED 评分对大出血的预测准确性优于 CHADS2 或 CHA2DS2-VASc 评分。
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How well does physician risk assessment predict stroke and bleeding in atrial fibrillation? Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).医生的风险评估对心房颤动患者中风和出血的预测效果如何?来自心房颤动更明智治疗结果登记处(ORBIT-AF)的结果。
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Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score.新型房颤抗凝出血风险评分对预测抗凝出血风险的比较验证:HAS-BLED(高血压、肾功能/肝功能异常、卒中、出血史或倾向、INR 易变、高龄、同时使用药物/酒精)评分。
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Performance of the HEMORR(2)HAGES, ATRIA, and HAS-BLED bleeding risk-prediction scores in patients with atrial fibrillation undergoing anticoagulation: the AMADEUS (evaluating the use of SR34006 compared to warfarin or acenocoumarol in patients with atrial fibrillation) study.在接受抗凝治疗的心房颤动患者中,HEMORR(2)HAGES、ATRIA 和 HAS-BLED 出血风险预测评分的表现:AMADEUS(评估 SR34006 与华法林或阿哌沙班在心房颤动患者中的比较)研究。
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Comparison of the CHADS2, CHA2DS2-VASc and HAS-BLED scores for the prediction of clinically relevant bleeding in anticoagulated patients with atrial fibrillation: the AMADEUS trial.比较 CHADS2、CHA2DS2-VASc 和 HAS-BLED 评分在预测抗凝治疗的心房颤动患者临床相关出血中的作用:AMADEUS 试验。
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