Hoek Rogier A S, Paats Marthe S, Pas Suzan D, Bakker Marleen, Hoogsteden Henk C, Boucher Charles A B, van der Eerden Menno M
Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, the Netherlands.
Scand J Infect Dis. 2013 Jan;45(1):65-9. doi: 10.3109/00365548.2012.708942. Epub 2012 Sep 19.
Respiratory infections caused by respiratory viruses are common in paediatric cystic fibrosis (CF) patients and are associated with increased morbidity. There is only little data on the incidence of viral respiratory pathogens causing exacerbations in the adult CF patient population. In this observational pilot study we show, by using molecular as well as conventional techniques for viral isolation, that during 1 y a viral pathogen could be isolated in 8/24 (33%) adult CF patients who presented with a pulmonary exacerbation. This result shows that there is a considerable incidence of viral pathogens in pulmonary exacerbations in adult CF patients. Newly identified viruses such as pandemic influenza A/H1N1, human metapneumovirus, human bocavirus, and human coronavirus NL63 were not detected in our population, except for 1 human coronavirus NL63.
呼吸道病毒引起的呼吸道感染在儿童囊性纤维化(CF)患者中很常见,且与发病率增加有关。关于导致成年CF患者病情加重的病毒性呼吸道病原体的发病率,仅有少量数据。在这项观察性试点研究中,我们通过使用分子技术以及传统病毒分离技术表明,在1年期间,8/24(33%)出现肺部病情加重的成年CF患者中可分离出病毒病原体。这一结果表明成年CF患者肺部病情加重时病毒病原体的发病率相当高。在我们的研究人群中未检测到新发现的病毒,如甲型H1N1大流行性流感病毒、人偏肺病毒、人博卡病毒和人冠状病毒NL63,但有1例人冠状病毒NL63。