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Formulation of vaccine adjuvant muramyldipeptides. 3. Processing optimization, characterization, and bioactivity of an emulsion vehicle.

作者信息

Lidgate D M, Fu R C, Byars N E, Foster L C, Fleitman J S

机构信息

Institute of Pharmaceutical Science, Syntex Research, Palo Alto, California 94304.

出版信息

Pharm Res. 1989 Sep;6(9):748-52. doi: 10.1023/a:1015915212195.

DOI:10.1023/a:1015915212195
PMID:2813271
Abstract

An efficacious vaccine adjuvant which elicits both cell-mediated immunity (CMI) and humoral immune response was developed using [thr1]-Muramyldipeptide (MDP) in an oil-in-water emulsion vehicle containing poloxamer 401, polysorbate 80, and squalane. Processing optimization was performed to increase the physical stability of this adjuvant emulsion which, when prepared by conventional mixing methods, demonstrated good bioactivity but poor physical stability. Various manufacturing methods were compared with a microfluidization process, which produced the most stable and elegant emulsion vehicle. The microfluidized emulsion also elicited equivalent biological response in the animal model tested.

摘要

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本文引用的文献

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Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.蛋白质和抗体研究的微量方法。I. 用鞣酸和蛋白质处理的红细胞进行血凝和血凝抑制反应的程序及一般应用。
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Sterile filtration of a parenteral emulsion.肠胃外乳剂的无菌过滤。
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非离子嵌段聚合物表面活性剂在体液免疫和细胞免疫中的佐剂作用。
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The adjuvant activity of nonionic block polymer surfactants. II. Antibody formation and inflammation related to the structure of triblock and octablock copolymers.非离子型嵌段聚合物表面活性剂的佐剂活性。II. 与三嵌段和八嵌段共聚物结构相关的抗体形成与炎症
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Characterization of liposomes prepared using a microemulsifier.使用微乳化剂制备的脂质体的表征
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The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.佐剂对体液免疫和细胞介导免疫的比较选择性。II. 弗氏不完全佐剂和完全佐剂、氢氧化铝凝胶、短小棒状杆菌、百日咳博德特氏菌、胞壁酰二肽和皂苷对小鼠和豚鼠迟发型超敏反应以及小鼠对肿瘤抗原的细胞介导免疫的影响
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The parenteral toxicity of clindamycin 2-phosphate in laboratory animals.克林霉素2-磷酸酯在实验动物中的注射毒性
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Stable oil-in-water emulsions: preparation and use as vaccine vehicles for lipophilic adjuvants.稳定的水包油乳液：制备及其作为亲脂性佐剂疫苗载体的应用
Vaccine. 1985 Jun;3(2):137-44. doi: 10.1016/0264-410x(85)90063-5.
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An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity.一种佐剂制剂，可选择性地引发保护性同种型抗体的形成和细胞介导的免疫反应。
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Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity.
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