Kozam G, Mantell G M
J Dent Res. 1978 Nov-Dec;57(11-12):954-7. doi: 10.1177/00220345780570110901.
Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed that eugenol caused denaturation of cytoplasmic proteins and loss of staining capacity of epithelium, loss of cell boundaries, swelling and cell necrosis. In addition, vesicle formation, edema in the corium, and striated muscle dissolution were observed.
将商业用途的100%浓度丁香酚涂抹于大鼠唇黏膜直径3毫米的限定区域，持续1分钟。随后设定15分钟、1小时、2小时、4小时和6小时的反应期。采用常规组织学程序处理实验组织，观察到丁香酚导致细胞质蛋白变性、上皮细胞染色能力丧失、细胞边界消失、肿胀及细胞坏死。此外，还观察到小泡形成、真皮水肿和横纹肌溶解。
