狂犬病病毒启发的二氧化硅包覆金纳米棒作为治疗脑肿瘤的光热治疗平台。
Rabies Virus-Inspired Silica-Coated Gold Nanorods as a Photothermal Therapeutic Platform for Treating Brain Tumors.
机构信息
School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
College of Pharmacy, Yeungnam University, Gyongsan, 38541, Republic of Korea.
出版信息
Adv Mater. 2017 Apr;29(13). doi: 10.1002/adma.201605563. Epub 2017 Jan 30.
Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the blood-brain barrier, and moreover respond to near-infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.
狂犬病病毒启发的二氧化硅包覆的金纳米棒通过模拟狂犬病病毒的大小、形状、表面糖蛋白特性和体内行为来制备。这些纳米棒不仅类似于实际狂犬病病毒的外观，而且还通过神经元途径绕过血脑屏障进入大脑，此外，它们还能响应近红外激光（808nm）照射，发出热量，并有效地抑制脑肿瘤。
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