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利用智能纳米颗粒对胶质母细胞瘤进行靶向治疗的新见解。

New insights into targeted therapy of glioblastoma using smart nanoparticles.

作者信息

Ghaznavi Habib, Afzalipour Reza, Khoei Samideh, Sargazi Saman, Shirvalilou Sakine, Sheervalilou Roghayeh

机构信息

Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

出版信息

Cancer Cell Int. 2024 May 7;24(1):160. doi: 10.1186/s12935-024-03331-3.

DOI:10.1186/s12935-024-03331-3
PMID:38715021
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11077767/
Abstract

In recent times, the intersection of nanotechnology and biomedical research has given rise to nanobiomedicine, a captivating realm that holds immense promise for revolutionizing diagnostic and therapeutic approaches in the field of cancer. This innovative fusion of biology, medicine, and nanotechnology aims to create diagnostic and therapeutic agents with enhanced safety and efficacy, particularly in the realm of theranostics for various malignancies. Diverse inorganic, organic, and hybrid organic-inorganic nanoparticles, each possessing unique properties, have been introduced into this domain. This review seeks to highlight the latest strides in targeted glioblastoma therapy by focusing on the application of inorganic smart nanoparticles. Beyond exploring the general role of nanotechnology in medical applications, this review delves into groundbreaking strategies for glioblastoma treatment, showcasing the potential of smart nanoparticles through in vitro studies, in vivo investigations, and ongoing clinical trials.

摘要

近年来，纳米技术与生物医学研究的交叉融合催生了纳米生物医学，这是一个引人入胜的领域，有望彻底改变癌症领域的诊断和治疗方法。生物学、医学和纳米技术的这种创新融合旨在创造出安全性和有效性更高的诊断和治疗药物，尤其是在针对各种恶性肿瘤的诊疗一体化领域。各种无机、有机以及有机 - 无机杂化纳米粒子，各自具有独特的性质，已被引入到这个领域。本综述旨在通过聚焦无机智能纳米粒子的应用，突出胶质母细胞瘤靶向治疗的最新进展。除了探讨纳米技术在医学应用中的一般作用外，本综述还深入研究了胶质母细胞瘤治疗的突破性策略，通过体外研究、体内研究以及正在进行的临床试验展示了智能纳米粒子的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/a2059909d323/12935_2024_3331_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/2a4b3234610b/12935_2024_3331_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/e8d0bccd2ecf/12935_2024_3331_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/a2059909d323/12935_2024_3331_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/2a4b3234610b/12935_2024_3331_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/e8d0bccd2ecf/12935_2024_3331_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11077767/a2059909d323/12935_2024_3331_Fig3_HTML.jpg

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引用本文的文献

[1]
Chemotherapeutic nanoparticles for glioblastoma.

Front Oncol. 2025-8-11

[2]
Graphene quantum dot-integrated nanocomposites: a promising avenue for glioblastoma treatment.

Med Oncol. 2025-8-8

[3]
Advanced nanotheranostic approaches for targeted glioblastoma treatment: a synergistic fusion of CRISPR-Cas gene editing, AI-driven tumor profiling, and BBB-modulation.

Med Oncol. 2025-8-7

[4]
Breaking Barriers in Glioblastoma Targeting through Advanced Nanoparticle Cell Membrane Coating.

ACS Appl Mater Interfaces. 2025-6-18

[5]
Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites.

Discov Oncol. 2025-5-9

[6]
Therapeutic Targets in Glioblastoma: Molecular Pathways, Emerging Strategies, and Future Directions.

Cells. 2025-3-26

[7]
Dynamic Tumor in Situ Fluid Circulating Tumor DNA Postsurgery Effectively Predicts Recurrence and Clinical Benefits for Glioblastomas.

Neurosurgery. 2025-3-5

[8]
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities.

Cancers (Basel). 2025-2-19

[9]
Synthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments.

BMC Cancer. 2025-1-8

[10]
Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives.

Pharmaceutics. 2024-7-15

本文引用的文献

[1]
From Trauma to Tumor: Exploring Post-Traumatic Brain Injury Glioblastoma Patient Characteristics.

World Neurosurg. 2024-4

[2]
Targeted Glioma Therapy-Clinical Trials and Future Directions.

Pharmaceutics. 2024-1-11

[3]
Glioblastoma Multiforme: The Latest Diagnostics and Treatment Techniques.

Pharmacology. 2023

[4]
An update in the applications of exosomes in cancer theranostics: from research to clinical trials.

J Cancer Res Clin Oncol. 2023-8

[5]
Carbon Dots: Opportunities and Challenges in Cancer Therapy.

Pharmaceutics. 2023-3-22

[6]
Advanced Bioinformatics Analysis and Genetic Technologies for Targeting Autophagy in Glioblastoma Multiforme.

Cells. 2023-3-15

[7]
Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment.

Nanomaterials (Basel). 2022-7-18

[8]
Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma.

Nat Commun. 2022-7-21

[9]
Multidrug Resistance in Cancer Cells: Focus on a Possible Strategy Plan to Address Colon Carcinoma Cells.

Life (Basel). 2022-5-30

[10]
TMZ magnetic temperature-sensitive liposomes-mediated magnetothermal chemotherapy induces pyroptosis in glioblastoma.

Nanomedicine. 2022-7

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