State Key Laboratory of Material Processing and Die & Mould Technology, School of Materials Science and Engineering , Huazhong University of Science and Technology (HUST) , Wuhan 430074 , P. R. China.
State Key Laboratory of Agricultural Microbiology, College of Science , Huazhong Agricultural University (HZAU) , Wuhan 430070 , P. R. China.
ACS Appl Mater Interfaces. 2018 Oct 31;10(43):36703-36710. doi: 10.1021/acsami.8b12758. Epub 2018 Oct 16.
Gold nanoparticles (AuNPs) exhibit great potential for biological applications due to their good biocompatibility and tunable localized surface plasmon resonance (LSPR) properties. Currently, although tuning the aspect ratio of a solid structure or designing a hollow structure has been performed to regulate the LSPR properties of AuNPs, the method of preparing hollow anisotropic AuNPs has rarely been reported. In this study, we designed gold hollow nanorods (AuHNRs) with controllable aspect ratios by a Se-doping Te nanorod-templated method with the assistance of l-cysteine. UV-vis-NIR spectra showed that AuHNRs with an aspect ratio of about 3 could have a LSPR peak in the second near-infrared (NIR-II) window, which is only half of the value required by traditional Au nanorods. Moreover, AuHNRs are nontoxic and capable of loading drugs. In vivo experiment revealed that AuHNRs can be used as contrast agents in multimodal imaging, including photothermal imaging, photoacoustic imaging, and computed tomography imaging, as well as in chemo-photothermal combined therapy of tumor in the NIR-II window. Because light in the NIR-II window has remarkable advantages over that in the first near-infrared (NIR-I) window in biomedical applications, AuHNRs can be used as promising NIR-II-window-responsive multifunctional nanoagents.
金纳米颗粒（AuNPs）由于其良好的生物相容性和可调谐的局域表面等离子体共振（LSPR）性质，在生物应用中具有巨大的潜力。目前，尽管已经通过调整固体结构的纵横比或设计空心结构来调节 AuNPs 的 LSPR 性质，但很少有报道制备空心各向异性 AuNPs 的方法。在这项研究中，我们通过硒掺杂碲纳米棒模板法，在半胱氨酸的辅助下，设计了具有可控纵横比的金空心纳米棒（AuHNRs）。紫外-可见-近红外光谱（UV-vis-NIR）表明，纵横比约为 3 的 AuHNRs 可以在第二个近红外（NIR-II）窗口中具有 LSPR 峰，这仅为传统 Au 纳米棒所需值的一半。此外，AuHNRs 具有低毒性且能够负载药物。体内实验表明，AuHNRs 可以用作多模态成像（包括光热成像、光声成像和计算机断层扫描成像）的造影剂，以及在 NIR-II 窗口中进行肿瘤的化学光热联合治疗。由于 NIR-II 窗口中的光在生物医学应用中比 NIR-I 窗口中的光具有显著优势，因此 AuHNRs 可用作有前途的 NIR-II 窗口响应多功能纳米制剂。
