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口服表面去乙酰化的几丁质纳米纤维和壳聚糖可抑制5-氟尿嘧啶诱导的小鼠肠道粘膜炎。

Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice.

作者信息

Koizumi Ryo, Azuma Kazuo, Izawa Hironori, Morimoto Minoru, Ochi Kosuke, Tsuka Takeshi, Imagawa Tomohiro, Osaki Tomohiro, Ito Norihiko, Okamoto Yoshiharu, Saimoto Hiroyuki, Ifuku Shinsuke

机构信息

Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.

Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan.

出版信息

Int J Mol Sci. 2017 Jan 27;18(2):279. doi: 10.3390/ijms18020279.

DOI:10.3390/ijms18020279
PMID:28134832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5343815/
Abstract

This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.

摘要

本研究调查了口服表面脱乙酰壳多糖纳米纤维（SDACNFs）和壳聚糖对5-氟尿嘧啶（5-FU）诱导的肠道黏膜炎的预防作用，5-氟尿嘧啶诱导的肠道黏膜炎是5-FU化疗常见的副作用。SDACNFs和壳聚糖消除了与肠道黏膜炎相关的组织学异常，并抑制了肠隐窝细胞的增殖不足和凋亡。这些结果表明，SDACNF和壳聚糖是预防抗癌药物诱导的黏膜炎的有效药物。

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