Doherty P C, Lane S J, Pfeil K A, Morgan W W, Bartke A, Smith M S
Department of Anatomy, University of Texas Health Science Center, San Antonio 78284.
Physiol Behav. 1989 Jun;45(6):1101-5. doi: 10.1016/0031-9384(89)90094-2.
Experiments were performed to determine if the inhibition of copulatory behavior observed in male rats with chronically elevated serum prolactin levels (hyperprolactinemia) is associated with changes in central dopaminergic function in the nigrostriatal and mesolimbic systems. Chronic hyperprolactinemia, induced by ectopic pituitary grafts, inhibited sexual activity but was not associated with changes in locomotor activity, serotyped behavior in response to various doses of apomorphine, or 3H-spiroperidol binding to striatal homogenates. However, open-field defecation was reduced in the pituitary grafted animals. The results of the present study show that changes in nigrostriatal dopamine receptor sensitivity do not contribute to the inhibition of sexual behavior in hyperprolactinemic male rats. In addition, these results also demonstrate that the effects of hyperprolactinemia are relatively specific to copulatory behavior and appear not to involve general behavioral suppression.
进行实验以确定在血清催乳素水平长期升高（高催乳素血症）的雄性大鼠中观察到的交配行为抑制是否与黑质纹状体和中脑边缘系统中枢多巴胺能功能的变化有关。由异位垂体移植诱导的慢性高催乳素血症抑制了性活动，但与运动活动的变化、对不同剂量阿扑吗啡的刻板行为反应或3H-螺哌啶醇与纹状体匀浆的结合无关。然而，垂体移植动物的旷场排便减少。本研究结果表明，黑质纹状体多巴胺受体敏感性的变化对高催乳素血症雄性大鼠性行为的抑制没有作用。此外，这些结果还表明，高催乳素血症的影响相对特定于交配行为，似乎不涉及一般行为抑制。
