温柏籽乙醇提取物局部应用对NC/Nga小鼠特应性皮炎样症状发展的影响。
Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice.
作者信息
Kawahara Takeshi, Tsutsui Kanako, Nakanishi Eri, Inoue Toshifumi, Hamauzu Yasunori
机构信息
Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano, 399-4598, Japan.
Research Center for Fungal & Microbial Dynamism, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano, 399-4598, Japan.
出版信息
BMC Complement Altern Med. 2017 Jan 31;17(1):80. doi: 10.1186/s12906-017-1606-6.
BACKGROUND
Quince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation.
METHODS
In the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice. The direct effect of QSEtE on keratinocytes was evaluated using the human keratinocyte cell line HaCaT.
RESULTS
The preliminary application of QSEtE markedly reduced house dust mite allergen-induced skin lesions. The expression of thymus- and activation-regulated chemokine (TARC) in dorsal skin was downregulated. QSEtE directly suppressed the expression and production of TARC in HaCaT cells.
CONCLUSIONS
The results suggest that the topical application of QSEtE is effective in preventing the onset of and ameliorating the atopic symptoms of keratinocyte-associated skin inflammation by suppressing TARC production in keratinocytes.
背景
榅桲（Cydonia oblonga Miller）是一种属于蔷薇科的落叶灌木。榅桲籽提取物长期以来因其保湿作用而被用作化妆品成分。然而，关于榅桲籽提取物对角质形成细胞相关的皮肤炎症是否具有治疗作用，人们知之甚少。
方法
在本研究中，我们研究了局部应用榅桲籽乙醇提取物（QSEtE）对NC/Nga小鼠特应性皮炎（AD）症状的影响。使用人角质形成细胞系HaCaT评估QSEtE对角质形成细胞的直接作用。
结果
预先应用QSEtE可显著减少屋尘螨过敏原诱导的皮肤损伤。背部皮肤中胸腺和活化调节趋化因子（TARC）的表达下调。QSEtE直接抑制HaCaT细胞中TARC的表达和产生。
结论
结果表明，局部应用QSEtE通过抑制角质形成细胞中TARC的产生，可有效预防角质形成细胞相关皮肤炎症的发作并改善其特应性症状。
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