Wu Han-Kuei, Ko Yu-Shien, Lin Yu-Sheng, Wu Hau-Tieng, Tsai Tung-Hu, Chang Hen-Hong
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Chinese Medicine, Taiwan Landseed Hospital, Tao-Yuan, Taiwan.
Division of Cardiology, Chang Gung Memorial Hospital, Taipei, Taiwan; College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Complement Ther Med. 2017 Feb;30:107-112. doi: 10.1016/j.ctim.2016.12.005. Epub 2016 Dec 21.
Our study aimed to correlate pulse wave parameters such as augmentation index (AI) and heart rate variability with traditional Chinese medicine (TCM) constitution for evaluating health status.
Out of 177 subjects, 69 healthy subjects were enrolled in the present study, and others were excluded because of cardiovascular, liver, kidney, or other diseases. Each subject was invited to complete pulse wave examination and the Constitution in Chinese Medicine Questionnaire. Independent Student's t-tests, Mann-Whitney tests, and binary logistic regression analysis were used to analyse the correlation between pulse wave parameters and TCM constitution.
Qi-deficient individuals had higher AI (p=0.006) and lower diastolic blood pressure (p=0.011); yang-deficient individuals had lower dP/dt max (p=0.030), systolic blood pressure (p=0.020), and pulse pressure (p=0.048); and damp-heat individuals had higher subendocardial viability index (SEVI) scores (p=0.011). We then categorized the phlegm dampness and yang-deficiency individuals into the cold group and those with damp-heat and yin-deficiency into the heat group. A comparison of the two constitution groups showed higher AI in the cold group (p=0.026). Binary logistic regression analysis demonstrated that only AI was a determinant, as evidenced by the finding that an increase of one unit in AI corresponded to an increase of 5% in the odds ratio for individuals to have a cold constitution (p=0.026).
Individuals with qi-deficient and cold constitutions had higher AI and lower SEVI, potentially reflecting an increase in arterial stiffness. This study can provide a basis for further investigation of the physiological indicators of TCM constitutions in modern medicine.
我们的研究旨在将诸如增强指数（AI）和心率变异性等脉搏波参数与中医体质相关联，以评估健康状况。
在177名受试者中，本研究纳入了69名健康受试者，其他受试者因患有心血管、肝脏、肾脏或其他疾病而被排除。邀请每位受试者完成脉搏波检查和中医体质问卷。采用独立样本t检验、曼-惠特尼检验和二元逻辑回归分析来分析脉搏波参数与中医体质之间的相关性。
气虚个体的AI较高（p = 0.006），舒张压较低（p = 0.011）；阳虚个体的dP/dt max较低（p = 0.030）、收缩压较低（p = 0.020）和脉压较低（p = 0.048）；湿热个体的心内膜下活力指数（SEVI）得分较高（p = 0.011）。然后，我们将痰湿和阳虚个体归为寒证组，将湿热和阴虚个体归为热证组。对这两种体质组进行比较，发现寒证组的AI较高（p = 0.026）。二元逻辑回归分析表明，只有AI是一个决定因素，这一发现证明，AI每增加一个单位，个体具有寒性体质的优势比就增加5%（p = 0.026）。
气虚和寒性体质的个体AI较高，SEVI较低，这可能反映了动脉僵硬度的增加。本研究可为进一步研究中医体质在现代医学中的生理指标提供依据。
