地塞米松对淋巴细胞亚群中细胞数量的影响：与重度抑郁症及地塞米松抑制试验非抑制性相关的变化

Dexamethasone effects on numbers of cells in lymphocyte subpopulations: changes associated with major depression and DST nonsuppression.

Pedersen C A, Folds J D, Evans D L

Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill.

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(6):895-906. doi: 10.1016/0278-5846(89)90041-9.

Abstract

The authors studied the effects of administration of 1 mg of dexamethasone on the number of cells in discrete subpopulations of lymphocytes in major depressed and psychiatric control patients with depressive symptoms. 2. Dexamethasone significantly decreased the total lymphocyte count and numbers of T and helper T lymphocytes in control patients. 3. In contrast, dexamethasone failed to significantly decrease the numbers of cells in any of the subpopulations of lymphocytes studied in major depressed patients. 4. Among major depressed patients both DST suppressors and nonsuppressors were insensitive to the suppressive effects of dexamethasone on lymphocyte numbers. 5. However, in DST nonsuppressors, but not in DST suppressors, dexamethasone administration significantly increased the number of cytotoxic/suppressor T lymphocytes and natural killer cells. 6. The authors conclude that insensitivity to the suppressive effects of dexamethasone on lymphocyte numbers is specific to major depression and is not associated with DST status. However, DST nonsuppression is associated with a facilitating effect of dexamethasone on the number of cells in some subpopulations of lymphocytes.

摘要

作者研究了给予1毫克地塞米松对重度抑郁症患者以及有抑郁症状的精神科对照患者淋巴细胞离散亚群中细胞数量的影响。2. 地塞米松显著降低了对照患者的总淋巴细胞计数以及T淋巴细胞和辅助性T淋巴细胞的数量。3. 相比之下，地塞米松未能显著降低重度抑郁症患者所研究的任何淋巴细胞亚群中的细胞数量。4. 在重度抑郁症患者中，地塞米松抑制试验（DST）的抑制者和非抑制者对其淋巴细胞数量的抑制作用均不敏感。5. 然而，在DST非抑制者中，而非DST抑制者中，给予地塞米松显著增加了细胞毒性/抑制性T淋巴细胞和自然杀伤细胞的数量。6. 作者得出结论，对糖皮质激素抑制试验对淋巴细胞数量抑制作用的不敏感性是重度抑郁症所特有的，且与DST状态无关。然而，DST非抑制与地塞米松对某些淋巴细胞亚群中细胞数量的促进作用有关。