Faculty of Medicine, Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.
National Institute of Rheumatic Diseases, Nabrezie I. Krasku 4, 921 12 Piestany, Slovakia.
Int J Mol Sci. 2022 Feb 24;23(5):2490. doi: 10.3390/ijms23052490.
Healing of articular cartilage defects presents a challenging issue, due to its regenerative shortcomings. Lacking vascularity and innervation of cartilage and low proliferative potential of chondrocytes are the main reasons for the limited healing potential of articular cartilage. Traditional reparative approaches are limited in their efficiency, hence there is a demand for novel reparative treatments. Mesenchymal stromal cells, preferred for clinical uses, can be readily derived from various sources and have been proven to have a therapeutic effect on cartilage and subchondral bone. Therefore, mesenchymal stromal cells, their derivates, and scaffolds have been utilized in research targeting osteochondral regeneration. The present review aims to comprehensively outline and discuss literature considering this topic published within last 5 years.
关节软骨缺损的愈合是一个具有挑战性的问题，这主要是由于其再生能力有限。软骨缺乏血管和神经支配以及软骨细胞的低增殖潜能是关节软骨愈合潜力有限的主要原因。传统的修复方法效率有限，因此需要新的修复治疗方法。间充质基质细胞因其在临床应用上的优势而被广泛应用，可从多种来源中轻易获得，并已被证明对软骨和软骨下骨具有治疗作用。因此，间充质基质细胞、其衍生物和支架已被用于针对骨软骨再生的研究。本文综述旨在全面概述和讨论过去 5 年内发表的关于这一主题的文献。
