加拿大耐环丙沙星的脑膜炎奈瑟菌：可能为输入菌株。
Ciprofloxacin-resistant Neisseria meningitidis in Canada: likely imported strains.
作者信息
Tsang Raymond S W, Law Dennis K S, Deng Saul, Hoang Linda
机构信息
a Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.
b BC Public Health Microbiology and Reference Laboratory, Vancouver, BC, Canada.
出版信息
Can J Microbiol. 2017 Mar;63(3):265-268. doi: 10.1139/cjm-2016-0716. Epub 2017 Jan 5.
The prevalence of ciprofloxacin-resistant Neisseria meningitidis in Canada was studied by testing 346 isolates received at the National Microbiology Laboratory during the calendar years 2013 to 2015. Of the 277 individual invasive and 69 noninvasive isolates tested, only 2 serogroup C (MenC) isolates were found to be resistant to ciprofloxacin. Both MenC were typed as sequence type (ST)-4821, a unique clone found mainly in China, thus suggesting both isolates might be from travel-related or imported cases. This prompted us to also examine 6 serogroup A (MenA) isolates in our collection, since MenA is not currently endemic in Canada. Three MenA from 2006 were resistant to ciprofloxacin and they were typed as ST-4789. A ciprofloxacin-resistant MenA strain of ST-4789 was responsible for a meningococcal disease outbreak in Delhi, India, in 2005 to 2006. The 2 MenC and 3 MenA ciprofloxacin-resistant N. meningitidis were from patients residing in British Columbia.
通过检测2013年至2015年期间国家微生物实验室收到的346株分离株，对加拿大环丙沙星耐药性脑膜炎奈瑟菌的流行情况进行了研究。在检测的277株侵袭性和69株非侵袭性分离株中，仅发现2株血清群C（MenC）分离株对环丙沙星耐药。这两株MenC均被分型为序列型（ST）-4821，这是一种主要在中国发现的独特克隆，因此表明这两株分离株可能来自与旅行相关或输入性病例。这促使我们也检查了我们收藏中的6株血清群A（MenA）分离株，因为MenA目前在加拿大并非地方流行。2006年的3株MenA对环丙沙星耐药，它们被分型为ST-4789。一株ST-4789的环丙沙星耐药性MenA菌株在2005年至2006年期间导致了印度德里的一次脑膜炎球菌病暴发。这2株MenC和3株MenA环丙沙星耐药性脑膜炎奈瑟菌来自居住在不列颠哥伦比亚省的患者。
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