Panos G D, Moschos M M, Kozeis N, Deshmukh R R, Mansouri K, Shaarawy T, Gatzioufas Z
Department of Ophthalmology, Ipswich Hospital NHS Trust, University of Cambridge, Ipswich, UK (Lead: Mr C. Edelsten).
Department of Ophthalmology, University of Athens, Greece (Head: Pr I. Ladas).
Klin Monbl Augenheilkd. 2017 Apr;234(4):464-467. doi: 10.1055/s-0042-119562. Epub 2017 Jan 31.
To investigate the state of dark adaptation and macular blood flow in different forms of glaucoma. Eighteen eyes of 18 patients with primary open-angle glaucoma, 14 eyes of 14 patients with pseudoexfoliation glaucoma, and 10 eyes of 10 patients with childhood glaucoma (CG) were examined by means of dark adaptometry, scanning-laser retinal flowmetry, and retinal tomography. All glaucomatous eyes had comparable optic disc excavation (one-way ANOVA, p = 0.138). Eyes with CG had significantly lower best-corrected visual acuity than the other groups (Tukey, all p < 0.0001). Macular perfusion was comparable in all three groups (one - way ANOVA, p = 0.08). The delay in rod-cone break time in the CG group was significantly higher than in the other groups (Tukey, all p < 0.0001). The scotopic sensitivity threshold in the CG group was significantly greater than in the other groups (Tukey, all p < 0.01). This underlying dysfunction of dark adaptation may contribute, at least to some extent, to the decreased visual perception observed in patients with CG.
研究不同类型青光眼患者的暗适应状态和黄斑血流情况。对18例原发性开角型青光眼患者的18只眼、14例假性剥脱性青光眼患者的14只眼以及10例儿童青光眼（CG）患者的10只眼进行了暗适应测量、扫描激光视网膜血流测量和视网膜断层扫描检查。所有青光眼患者的视盘凹陷程度相当（单因素方差分析，p = 0.138）。CG组患者的最佳矫正视力显著低于其他组（Tukey检验，所有p < 0.0001）。三组患者的黄斑灌注情况相当（单因素方差分析，p = 0.08）。CG组的视锥视杆细胞转换时间延迟显著高于其他组（Tukey检验，所有p < 0.0001）。CG组的暗视敏感度阈值显著高于其他组（Tukey检验，所有p < 0.01）。这种潜在的暗适应功能障碍可能至少在一定程度上导致了CG患者视觉感知下降。
