在F1小鼠红白血病进展过程中，抗体诱导的Friend病毒白血病细胞表面抗原丢失发生。
Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice.
作者信息
Doig D, Chesebro B
出版信息
J Exp Med. 1978 Nov 1;148(5):1109-21. doi: 10.1084/jem.148.5.1109.
Abstract
Friend virus (FV)-induced leukemic spleen cells from (B10.A X A)F1 mice were found to lose sensitivity to antibody-mediated lysis during progression of erythroleukemia. This was correlated with a 78% loss of FV-induced cell surface antigens as determined by quantitative absorption of cytotoxic antibodies and with a decreased percentage of leukemic spleen cells showing membrane immunofluorescence with anti-FV antibody. Antigen loss was observed only with virus-induced antigens, and was limited to antigens expressed on the cell surface. FV-induced antigens were regained when low-antigen leukemia cells from late stages of the leukemia were transferred to lethally irradiated nonimmune recipients, but not when these cells were transferred to hyperimmune lethally irradiated recipients. Conversely, when high-antigen leukemic spleen cells from early stages of the erythroleukemia were transferred to hyperimmune irradiated recipients, antigen loss was induced. The immune response to virus-induced antigens appeared to be involved in causing the antigenic changes observed on leukemia cells in this system.
摘要
在红白血病进展过程中，发现来自（B10.A×A）F1小鼠的Friend病毒（FV）诱导的白血病脾细胞对抗体介导的裂解失去敏感性。通过细胞毒性抗体的定量吸收测定，这与FV诱导的细胞表面抗原损失78%相关，并且与用抗FV抗体显示膜免疫荧光的白血病脾细胞百分比降低相关。仅在病毒诱导的抗原中观察到抗原丢失，并且仅限于细胞表面表达的抗原。当白血病晚期低抗原白血病细胞转移至致死性照射的非免疫受体时，FV诱导的抗原得以恢复，但转移至超免疫致死性照射受体时则不然。相反，当红白血病早期高抗原白血病脾细胞转移至超免疫照射受体时，会诱导抗原丢失。对病毒诱导抗原的免疫反应似乎参与了该系统中白血病细胞上观察到的抗原变化。
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Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice.在F1小鼠红白血病进展过程中，抗体诱导的Friend病毒白血病细胞表面抗原丢失发生。
J Exp Med. 1978 Nov 1;148(5):1109-21. doi: 10.1084/jem.148.5.1109.
2
Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.抗Friend病毒抗体与白血病小鼠病毒血症的恢复及病毒白血病细胞表面抗原的丧失有关。鉴定Rfv-3为影响抗体产生的基因座。
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Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.抗体诱导的Friend病毒细胞表面抗原调节可降低持续性红白血病细胞的病毒产生：Rfv-3基因的影响。
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Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus.Friend红白血病抗原。一种由脾集落形成病毒指定的病毒抗原，以及受Fv-2基因座控制的分化抗原。
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New cell surface gp70 related to Friend mink cell focus-inducing virus is expressed on Friend virus-induced erythroleukemic spleen cells after elimination of ecotropic Friend virus gp70 in Rfv-3r/s mice.与弗氏水貂细胞灶诱导病毒相关的新细胞表面糖蛋白70，在Rfv-3r/s小鼠中消除嗜异性弗氏病毒糖蛋白70后，表达于弗氏病毒诱导的红白血病脾细胞上。
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Expression of virus-associated antigens and immune cell functions during spontaneous regression of the Friend viral murine leukemia.弗氏病毒诱导的小鼠白血病自然消退过程中病毒相关抗原的表达及免疫细胞功能
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H-2D (Rfv-1) gene influence on recovery from Friend virus leukemia is mediated by nonleukemic cells of the spleen and bone marrow.H-2D（Rfv-1）基因对从弗氏病毒白血病中恢复的影响是由脾脏和骨髓的非白血病细胞介导的。
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Shut-down of virus synthesis during progression of erythroleukemia induced by Friend virus in mice.在小鼠中由弗氏病毒诱导的红白血病进展过程中病毒合成的停止。
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G(AKSL2): a new cell surface antigen of the mouse related to the dualtropic mink cell focus-inducing class of murine leukemia virus detected by naturally occurring antibody.G(AKSL2)：一种与双嗜性水貂细胞融合诱导型鼠白血病病毒相关的小鼠新细胞表面抗原，由天然存在的抗体检测到。
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引用本文的文献
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Plasma membrane glycoproteins encoded by cloned Rauscher and Friend spleen focus-forming viruses.由克隆的劳舍尔和弗瑞德脾脏集落形成病毒编码的质膜糖蛋白。
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New cell surface gp70 related to Friend mink cell focus-inducing virus is expressed on Friend virus-induced erythroleukemic spleen cells after elimination of ecotropic Friend virus gp70 in Rfv-3r/s mice.与弗氏水貂细胞灶诱导病毒相关的新细胞表面糖蛋白70，在Rfv-3r/s小鼠中消除嗜异性弗氏病毒糖蛋白70后，表达于弗氏病毒诱导的红白血病脾细胞上。
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Replication-defective Friend murine leukemia virus particles containing uncleaved gag polyproteins and decreased levels of envelope glycoprotein.含有未切割的gag多聚蛋白且包膜糖蛋白水平降低的复制缺陷型Friend小鼠白血病病毒颗粒。
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Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.抗体诱导的Friend病毒细胞表面抗原调节可降低持续性红白血病细胞的病毒产生：Rfv-3基因的影响。
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Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia.病毒诱导的红细胞白血病自然恢复后，感染性弗氏病毒在小鼠脾脏中的持续存在。
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Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.抗Friend病毒抗体与白血病小鼠病毒血症的恢复及病毒白血病细胞表面抗原的丧失有关。鉴定Rfv-3为影响抗体产生的基因座。
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本文引用的文献
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ASSAY FOR FRIEND LEUKEMIA VIRUS: RAPID QUANTITATIVE METHOD BASED ON ENUMERATION OF MACROSCOPIC SPLEEN FOCI IN MICE.Friend白血病病毒检测：基于小鼠脾脏肉眼可见病灶计数的快速定量方法。
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Pathogenesis of mouse leukemia caused by Friend virus.弗瑞德病毒引发的小鼠白血病的发病机制。
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Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.具有白血病特征的疾病在成年瑞士小鼠中的无细胞传播。
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Antigenic modulation. Loss of TL antigen from cells exposed to TL antibody. Study of the phenomenon in vitro.抗原调制。暴露于TL抗体的细胞中TL抗原的丧失。该现象的体外研究。
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Suppression of Gross leukemia cell-surface antigens: a kind of antigenic modulation.白血病细胞总表面抗原的抑制：一种抗原调变。
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Transformation of spleen cells three hours after infection in vivo with Friend leukemia virus.
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The separation of different cell classes from lymphoid organs. V. Simple procedures for the removal of cell debris. Damaged cells and erythroid cells from lymphoid cell suspensions.从淋巴器官中分离不同细胞类别。五、去除细胞碎片的简单程序。淋巴样细胞悬液中的受损细胞和红细胞。
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Modulation of fetal antigen(s) in mouse leukemia cells.小鼠白血病细胞中胎儿抗原的调节
Cancer Res. 1974 Jun;34(6):1366-71.
9
Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex.宿主对弗氏白血病病毒诱导的脾肿大恢复的遗传控制：主要组织相容性复合体内一个基因的定位
J Exp Med. 1974 Dec 1;140(6):1457-67. doi: 10.1084/jem.140.6.1457.
10
Induction of partial immunologic tolerance in rats and progressive loss of cellular antigenicity in Gross virus lymphoma.大鼠部分免疫耐受性的诱导及格罗斯病毒淋巴瘤细胞抗原性的逐渐丧失。
J Exp Med. 1974 Jun 1;139(6):1382-94. doi: 10.1084/jem.139.6.1382.
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