Perrier E T, Bottin J H, Vecchio M, Lemetais G
Danone Research, RD 128, Palaiseau Cedex, France.
Eur J Clin Nutr. 2017 Apr;71(4):561-563. doi: 10.1038/ejcn.2016.269. Epub 2017 Feb 1.
Growing evidence suggests a distinction between water intake necessary for maintaining a euhydrated state, and water intake considered to be adequate from a perspective of long-term health. Previously, we have proposed that maintaining a 24-h urine osmolality (U) of ⩽500 mOsm/kg is a desirable target for urine concentration to ensure sufficient urinary output to reduce renal health risk and circulating vasopressin. In clinical practice and field monitoring, the measurement of U is not practical. In this analysis, we calculate criterion values for urine-specific gravity (U) and urine color (U), two measures which have broad applicability in clinical and field settings. A receiver operating characteristic curve analysis performed on 817 urine samples demonstrates that a U ⩾1.013 detects U>500 mOsm/kg with very high accuracy (AUC 0.984), whereas a subject-assessed U⩾4 offers high sensitivity and moderate specificity (AUC 0.831) for detecting U >500 m Osm/kg.
越来越多的证据表明,维持正常水合状态所需的饮水量与从长期健康角度来看被认为充足的饮水量之间存在差异。此前,我们曾提出,将24小时尿渗透压(U)维持在≤500 mOsm/kg是理想的尿液浓缩目标,以确保足够的尿量输出,降低肾脏健康风险并减少循环血管加压素。在临床实践和现场监测中,测量尿渗透压并不实际。在本分析中,我们计算了尿比重(U)和尿色(U)的标准值,这两种测量方法在临床和现场环境中具有广泛的适用性。对817份尿液样本进行的受试者工作特征曲线分析表明,尿比重U≥1.013能以非常高的准确性检测出U>500 mOsm/kg(曲线下面积0.984),而受试者评估的尿色U≥4对于检测U>500 mOsm/kg具有高灵敏度和中等特异性(曲线下面积0.831)。