Université Paris–Diderot, Paris 7, Paris, France.
Diabetes Care. 2011 Dec;34(12):2551-4. doi: 10.2337/dc11-0652. Epub 2011 Oct 12.
Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes.
Participants were 3,615 middle-aged men and women, with normal baseline fasting glycemia (FG), who were recruited in a 9-year follow-up study. Odds ratios (ORs) and 95% CIs for the incidence of hyperglycemia (FG ≥6.1 mmol/L or treatment for diabetes) were calculated according to daily water intake classes based on a self-administered questionnaire.
During follow-up, there were 565 incident cases of hyperglycemia. After adjustment for confounding factors, ORs (95% CIs) for hyperglycemia associated with classes of water intake (<0.5 L, n = 677; 0.5 to <1.0 L, n = 1,754; and >1.0 L, n = 1,184) were 1.00, 0.68 (0.52-0.89), and 0.79 (0.59-1.05), respectively (P = 0.016).
Self-reported water intake was inversely and independently associated with the risk of developing hyperglycemia.
水的摄入会改变血管加压素的分泌。最近的研究结果表明，血浆 copeptin（血管加压素的替代物）与糖尿病风险之间存在独立关联。
参与者为 3615 名中年男女，他们在基线时空腹血糖正常（FG），并在 9 年的随访研究中被招募。根据自我管理问卷，根据每日水摄入量分类，计算了发生高血糖（FG≥6.1mmol/L 或糖尿病治疗）的几率比（OR）和 95%置信区间（CI）。
随访期间，有 565 例高血糖事件。在调整了混杂因素后，与水摄入量分类（<0.5L，n=677；0.5 至<1.0L，n=1754；和>1.0L，n=1184）相关的高血糖发生几率的 OR（95%CI）分别为 1.00、0.68（0.52-0.89）和 0.79（0.59-1.05）（P=0.016）。
自我报告的水摄入量与发生高血糖的风险呈负相关且独立相关。
