Neidell Matthew, Lamster Ira B, Shearer Barbara
Department of Health Policy & Management, Columbia University Mailman School of Public Health, New york, NY, USA.
Colgate Oral Pharmaceuticals, New york, NY, USA.
Community Dent Oral Epidemiol. 2017 Jun;45(3):275-280. doi: 10.1111/cdoe.12286. Epub 2017 Feb 1.
To analyse the cost-effectiveness of a screening programme and follow-up interventions for persons with dysglycemia who are identified during a dental visit.
This study is a secondary analysis utilizing data from two relevant publications. Those studies identified persons with dysglycemia who were seen in a dental school clinic for routine dental care and determined compliance with a recommendation to seek medical care. The response site was 59.4%. The Archimedes disease simulation model was utilized to simulate the effect of a weight loss programme for identified subjects on several outcomes.
Two scenarios for weight loss programmes were considered: a 10% permanent loss in body weight and a 10% loss that decays over time. Both diabetes and prediabetes were analysed. The decay path costs $21 243 per quality adjusted life year (QALY) with 3 years required to achieve the weight reduction. This cost decreases to $6655 if only 1 year is needed to achieve the weight goal. Without decay, the cost per QALY is $15 873 with 20 years of intervention, vs $647 per QALY with 10 years of intervention. For individuals with type 2 diabetes mellitus, the cost per QALY is $48 604 to $56 207 depending on adherence. With the addition of oral medication (a sulfonylurea), the cost is three times higher.
Under the conditions described here, identification of persons with dysglycemia in the dental office for initiating prediabetic care is a cost-effective means of identifying and treating affected individuals.
分析针对在牙科就诊时被确诊为血糖异常者的筛查项目及后续干预措施的成本效益。
本研究是一项二次分析,利用了两篇相关出版物的数据。这些研究确定了在牙科学院诊所接受常规牙科护理时被诊断为血糖异常的患者,并确定了他们对寻求医疗建议的依从性。回应率为59.4%。采用阿基米德疾病模拟模型来模拟为已确定的受试者制定的减肥计划对多个结局的影响。
考虑了两种减肥计划方案:体重永久性减轻10%和体重随时间逐渐减轻10%。对糖尿病和糖尿病前期均进行了分析。逐渐减轻体重的方案每获得一个质量调整生命年(QALY)的成本为21243美元,实现体重减轻需要3年时间。如果只需1年就能实现体重目标,成本将降至6655美元。若体重不逐渐减轻,20年干预的每QALY成本为15873美元,而10年干预的每QALY成本为647美元。对于2型糖尿病患者,根据依从性不同,每QALY成本为48604美元至56207美元。若加用口服药物(一种磺脲类药物),成本会高出三倍。
在本文所述条件下,在牙科诊所识别血糖异常者以启动糖尿病前期护理是识别和治疗受影响个体的一种具有成本效益的方法。