Lee Seung Hyen, Kim Tae-Woo, Lee Eun Ji, Girard Michaël J A, Mari Jean Martial
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Biomedical Engineering, National University of Singapore, Singapore 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):755-762. doi: 10.1167/iovs.16-20802.
To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes.
Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, sex, and axial length were included. The LCD and lamina cribrosa curvature index (LCCI) were measured in B-scan images obtained using swept-source optical coherence tomography at seven locations spaced equidistantly across the vertical optic disc diameter. The mean values of the measurements made at seven points of the LC were defined as the average LCD and LCCI.
The average LCD (527.0 ± 116.4 vs. 413.3 ± 80.4 μm, P < 0.001) and average LCCI (10.97 ± 2.59 vs. 6.81 ± 1.43, P < 0.001) were significantly larger in POAG eyes than in the matched healthy subjects (all seven locations, P < 0.001). The area under the receiver operating characteristic curve (AUC) was significantly larger for the LCCI than the LCD (0.921 vs. 0.784, P < 0.001). The intraocular pressure was positively associated with average LCD and LCCI in healthy subjects (P = 0.021 and P < 0.001, respectively) and POAG patients (P = 0.011 and P < 0.001, respectively). Male sex was associated with larger average LCCI (P = 0.013) and LCD (P = 0.008) in POAG.
The LCCI had significantly better discriminating capability between POAG and healthy eyes than LCD. This finding suggests that the LCCI may serve better than the LCD for improved glaucoma management.
比较筛板深度（LCD）和筛板（LC）曲率在鉴别原发性开角型青光眼（POAG）患眼与健康眼方面的能力。
纳入77例POAG患者的77只患眼以及77名年龄、性别和眼轴长度相匹配的健康受试者的77只眼睛。使用扫频源光学相干断层扫描在垂直视盘直径上等距分布的七个位置获取B扫描图像，测量LCD和筛板曲率指数（LCCI）。将在LC七个点处测量的平均值定义为平均LCD和LCCI。
POAG患眼中的平均LCD（527.0±116.4 vs. 413.3±80.4μm，P<0.001）和平均LCCI（10.97±2.59 vs. 6.81±1.43，P<0.001）显著大于匹配的健康受试者（所有七个位置，P<0.001）。LCCI的受试者操作特征曲线下面积（AUC）显著大于LCD（0.921 vs. 0.784，P<0.001）。在健康受试者（分别为P = 0.021和P<0.001）和POAG患者（分别为P = 0.011和P<0.001）中，眼压与平均LCD和LCCI呈正相关。在POAG中，男性与较大的平均LCCI（P = 0.013）和LCD（P = 0.008）相关。
LCCI在鉴别POAG与健康眼方面的鉴别能力明显优于LCD。这一发现表明，LCCI可能比LCD更有助于改善青光眼的管理。
