Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Am J Ophthalmol. 2021 Mar;223:1-8. doi: 10.1016/j.ajo.2020.09.028. Epub 2020 Sep 21.
To compare lamina cribrosa curvature (LCC) in pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG) and to elucidate the factors associated with LCC in both groups.
Retrospective, cross-sectional study.
Forty eyes with PXG and visual field mean deviation-matched 40 eyes with POAG were included. Spectral domain optical coherence tomography enhanced depth imaging was used to acquire LC images. The LCC index (LCCI) was calculated as LCC depth/LCC width × 100. Calculated LCCI values were compared between the PXG and POAG groups. Logistic regression analysis was performed to investigate the factors related to the presence of PXG. Factors associated with LCCI were determined by uni- and multivariable linear regression analyses in both groups.
Visual field mean deviation (-11.7 ± 9.7 dB vs -1.0 ± 8.5 dB, P = .731) and retinal nerve fiber thickness (647.4 ± 22.7 μm vs 68.3 ± 19.9 μm, P = .857) did not differ between the 2 groups. However, the mean (8.8 ± 2.9 in PXG, 6.6 ± 1.9 in POAG) and sectoral LCCIs assessed at 0, 30, 60, 90, and 120° were significantly greater in the PXG than in the POAG group (all, P < .05), but not at 150° (P = .113). Logistic regression analysis revealed that higher average LCCI (odds ratio [OR] = 1.509 [95% confidence interval 1.180-2.047], P = .003) and older age (OR = 1.074 [95% confidence interval 1.017-1.147], P = .019) were associated with the presence of PXG. IOP was associated with mean LCCI only in the POAG group (β = 0.150 [95% confidence interval 0.018-0.281], P = .027) while none of the factors showed association with LCCI in PXG.
PXG eyes had more steeply curved LC than POAG eyes with a similar level of glaucoma severity. The clinical implication(s) of steeper LCC in PXG should be investigated in a forthcoming study.
比较假性剥脱综合征（PXG）和原发性开角型青光眼（POAG）的视盘筛板层曲率（LCC），并阐明两组中与 LCC 相关的因素。
回顾性、横断面研究。
纳入 40 只 PXG 眼和视野平均偏差匹配的 40 只 POAG 眼。使用谱域光学相干断层扫描增强深度成像获取 LC 图像。计算 LCC 指数（LCCI）作为 LCC 深度/LCC 宽度×100。比较 PXG 和 POAG 组之间的 LCCI 值。进行逻辑回归分析以调查与 PXG 存在相关的因素。在两组中，通过单变量和多变量线性回归分析确定与 LCCI 相关的因素。
两组间视野平均偏差（-11.7 ± 9.7 dB 与-1.0 ± 8.5 dB，P =.731）和视网膜神经纤维厚度（647.4 ± 22.7 μm 与 68.3 ± 19.9 μm，P =.857）无差异。然而，在 0、30、60、90 和 120°处评估的平均（PXG 为 8.8 ± 2.9，POAG 为 6.6 ± 1.9）和节段性 LCCI 在 PXG 组中显著大于 POAG 组（均，P <.05），但在 150°处无差异（P =.113）。逻辑回归分析显示，较高的平均 LCCI（优势比[OR] = 1.509[95%置信区间 1.180-2.047]，P =.003）和年龄较大（OR = 1.074[95%置信区间 1.017-1.147]，P =.019）与 PXG 的存在相关。IOP 仅与 POAG 组的平均 LCCI 相关（β= 0.150[95%置信区间 0.018-0.281]，P =.027），而 PXG 中没有任何因素与 LCCI 相关。
PXG 眼的 LC 比 POAG 眼更陡峭，尽管青光眼严重程度相似。在未来的研究中，应该研究 PXG 中更陡峭的 LCC 的临床意义。
