Ray Subhasree, Kalia Vipin Chandra
Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.
Academy of Scientific and Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi, 110001 India.
Indian J Microbiol. 2017 Mar;57(1):39-47. doi: 10.1007/s12088-016-0622-4. Epub 2016 Sep 28.
Polyhydroxyalkanoate (PHAs) are natural, biodegradable biopolymers, which can be produced from renewable materials. PHAs have potential to replace petroleum derived plastics. Quite a few bacteria can produce PHA under nutritional stress. They generally produce homopolymers of butyrate i.e., polyhydroxybutyrate (PHB), as a storage material. The biochemical characteristics of PHB such as brittleness, low strength, low elasticity, etc. make these unsuitable for commercial applications. Co-polymers of PHA, have high commercial value as they overcome the limitations of PHBs. Co-polymers can be produced by supplementing the feed with volatile fatty acids or through hydrolysates of different biowastes. In this review, we have listed the potential bacterial candidates and the substrates, which can be co-metabolized to produce PHA co-polymers.
聚羟基脂肪酸酯(PHA)是天然的、可生物降解的生物聚合物,可由可再生材料生产。PHA有潜力替代石油衍生塑料。不少细菌在营养胁迫下能产生PHA。它们通常产生丁酸的均聚物,即聚羟基丁酸酯(PHB),作为储存材料。PHB的生化特性,如脆性、低强度、低弹性等,使其不适合商业应用。PHA的共聚物具有很高的商业价值,因为它们克服了PHB的局限性。共聚物可以通过在饲料中添加挥发性脂肪酸或通过不同生物废料的水解产物来生产。在这篇综述中,我们列出了潜在的细菌候选菌株和底物,它们可以被共代谢以生产PHA共聚物。