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巧茶对记忆的毒性作用:系统评价与荟萃分析。

Toxic effect of khat () on memory: Systematic review and meta-analysis.

作者信息

Berihu Birhane Alem, Asfeha Gebrekidan Gebregzabher, Welderufael Abadi Leul, Debeb Yared Godefa, Zelelow Yibrah Berhe, Beyene Hafte Assefa

机构信息

Department of Anatomy and Histology, Institute of Bio-Medical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Department of Biochemistry and Molecular Biology, Institute of Bio-Medical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

出版信息

J Neurosci Rural Pract. 2017 Jan-Mar;8(1):30-37. doi: 10.4103/0976-3147.193524.

DOI:10.4103/0976-3147.193524
PMID:28149078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5225718/
Abstract

BACKGROUND

People use khat () for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis.

OBJECTIVE

We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat ( Forsk) on memory discrepancy.

METHODS

MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review. Keywords utilized across database search were khat, cat, chat, long-term memory, short-term memory, memory deficit, randomized control trial, and cross-sectional survey. The search was limited to studies in humans and rodents; published in English language.

RESULT

Finding of various studies included in our meta-analysis showed that the effect of acute, and subchronic exposure to khat showed that short-term memory appears to be affected depending on the duration of exposure. However, does not have any effect on long-term memory.

CONCLUSION

Although a number of studies regarding the current topic are limited, the evidenced showed that khat () induced memory discrepancy.

摘要

背景

人们使用巧茶是因其对身体活动、意识、运动和心理功能具有令人愉悦的刺激作用。尽管有报告评估了巧茶对记忆的影响,但尚无基于正式系统评价和荟萃分析的研究。

目的

因此,我们进行了这项荟萃分析,以确定巧茶(Forsk)对记忆差异影响的证据水平。

方法

检索了MEDLINE、Cochrane图书馆、PubMed、学术搜索完整版、体育文献数据库、ScienceDirect、Scopus、科学网和谷歌学术,以获取本综述的论文。在数据库搜索中使用的关键词有巧茶、恰特草、聊天、长期记忆、短期记忆、记忆缺陷、随机对照试验和横断面调查。搜索仅限于人类和啮齿动物的研究;以英文发表。

结果

我们荟萃分析中纳入的各种研究结果表明,急性和亚慢性接触巧茶的影响表明,短期记忆似乎会受到接触持续时间的影响。然而,对长期记忆没有任何影响。

结论

尽管关于当前主题的一些研究有限,但证据表明巧茶会导致记忆差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/290bcb95a537/JNRP-8-30-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/32c0de9ed05f/JNRP-8-30-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/53694b86fffd/JNRP-8-30-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/18212d062b0d/JNRP-8-30-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/d4147400e4ff/JNRP-8-30-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/290bcb95a537/JNRP-8-30-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/32c0de9ed05f/JNRP-8-30-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/53694b86fffd/JNRP-8-30-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/18212d062b0d/JNRP-8-30-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/d4147400e4ff/JNRP-8-30-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd2a/5225718/290bcb95a537/JNRP-8-30-g006.jpg

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Catha edulis deteriorates spatial working memory in rats, but spares reference memory.巧茶会损害大鼠的空间工作记忆,但不影响参考记忆。
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