Cai Xiaoying, Shi Xiaolei, Zhang Ximeng, Zhang Aiwu, Zheng Minying, Fang Yannan
Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, 510080, China.
Department of Neurology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Anhui, 241001, China.
J Headache Pain. 2017 Dec;18(1):13. doi: 10.1186/s10194-017-0725-2. Epub 2017 Feb 2.
Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migraine. However, their roles in this disorder are not well established. Then we conduct this meta-analysis to address this issue.
PubMed, Web of Science and Cochrane databases were systematically searched to identify all relevant studies. Odds ratio (OR) with corresponding 95% confidence interval (CI) was used to estimate the strength of association between BDNF gene rs6265 and rs2049046 polymorphism and migraine.
Four studies with 1598 cases and 1585 controls, fulfilling the inclusion criteria were included in our meta-analysis. Overall data showed significant association between rs6265 polymorphism and migraine in allele model (OR = 0.86, 95%CI: 0.76-0.99, p = 0.03), recessive model (OR = 0.84, 95%CI: 0.72-0.98, p = 0.03) and additive model (GG vs GA: OR = 0.85, 95%CI: 0.72-1.00, p = 0.04), respectively. We also found significant association between rs2049046(A/T) polymorphism and migraine in allele model (OR = 0.88, 95%CI: 0.79-0.98, p = 0.02), recessive model (OR = 0.80, 95%CI: 0.67-0.96, p = 0.02) and additive model (AA vs TT: OR = 0.72, 95%CI: 0.57-0.92, p = 0.008; AA vs AT: OR = 0.81, 95%CI: 0.67-0.99, p = 0.03), respectively.
Our meta-analysis suggested that BDNF rs6265 and rs2049046 polymorphism were associated with common migraine in Caucasian population. Further studies are awaited to update this finding in Asian population and other types of migraine.
偏头痛是一种与基因变异相关的复发性头痛疾病。已发现脑源性神经营养因子（BDNF）基因rs6265（Val66Met）和rs2049046多态性与偏头痛有关。然而，它们在这种疾病中的作用尚未完全明确。因此，我们进行了这项荟萃分析以解决这一问题。
系统检索PubMed、Web of Science和Cochrane数据库，以识别所有相关研究。采用比值比（OR）及相应的95%置信区间（CI）来估计BDNF基因rs6265和rs2049046多态性与偏头痛之间的关联强度。
四项研究共纳入1598例病例和1585例对照，均符合纳入标准。总体数据显示，rs6265多态性与偏头痛在等位基因模型（OR = 0.86，95%CI：0.76 - 0.99，p = 0.03）、隐性模型（OR = 0.84，95%CI：0.72 - 0.98，p = 0.03）和加性模型（GG与GA相比：OR = 0.85，95%CI：0.72 - 1.00，p = 0.04）中均存在显著关联。我们还发现，rs2049046（A/T）多态性与偏头痛在等位基因模型（OR = 0.88，95%CI：0.79 - 0.98，p = 0.02）、隐性模型（OR = 0.80，95%CI：0.67 - 0.96，p = 0.02）和加性模型（AA与TT相比：OR = 0.72，95%CI：0.57 - 0.92，p = 0.008；AA与AT相比：OR = 0.81，95%CI：0.67 - 0.99，p = 0.03）中也均存在显著关联。
我们的荟萃分析表明，BDNF rs6265和rs2049046多态性与白种人群中的常见偏头痛有关。有待进一步研究以更新亚洲人群及其他类型偏头痛的这一发现。
