Park Sun Hwa, Yun Byeong Gon, Won Joo Yun, Yun Won Soo, Shim Jin Hyung, Lim Mi Hyun, Kim Do Hyun, Baek Sang A, Alahmari Yahya Dhafer, Jeun Jun Ho, Hwang Se Hwan, Kim Sung Won
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Laryngoscope. 2017 May;127(5):1036-1043. doi: 10.1002/lary.26400. Epub 2017 Feb 1.
Polycaprolactone (PCL) is an U.S. Food and Drug Administration-approved synthetic biodegradable polymer and is easily fabricated into three-dimensional (3D) structures. In this study, the 3D-printed PCL implant for nasal augmentation was further evaluated for its suitability for nasal surgeries such as septoplasty and rhinoplasty.
Ten New Zealand White rabbits were included and divided into study and sham groups (7 and 3, respectively). A lateral incision was made on the nasal dorsum and a pocket formed in the subperichondrial plane between the upper lateral cartilage and nasal septum. Polycaprolactone was fabricated based on 3D printing technology into a 0.8 × 0.8-cm rectangular shape for use as a nasal implant. The material was inserted as a septal extension graft and sutured with alar cartilage for nasal reshaping. The implants were harvested 4, 8, and 12 weeks after implantation and evaluated by gross morphological assessment and histological examination.
The initial shape of the implant was unchanged in all cases, and no definitive postoperative complications were seen over the 3-month period. Gross morphological evaluation confirmed that implants remained in their initial location without migration or extrusion. Histologic evaluations showed that the implant architectures were maintained with excellent fibrovascular ingrowth and minimal inflammatory reactions.
Polycaprolactone can be used for nasal reconstruction such as nasal augmentation. Polycaprolactone is easy to work with and will avoid the increased operative time and morbidity associated with autograft harvesting. Therefore, PCL implants designed by 3D printing can serve as clinically biocompatible materials in craniofacial reconstruction in the future.
NA. Laryngoscope, 127:1036-1043, 2017.
聚己内酯（PCL）是一种经美国食品药品监督管理局批准的合成可生物降解聚合物，易于制成三维（3D）结构。在本研究中，对用于隆鼻的3D打印PCL植入物在鼻中隔成形术和隆鼻术等鼻部手术中的适用性进行了进一步评估。
纳入10只新西兰白兔，分为研究组和假手术组（分别为7只和3只）。在鼻背做外侧切口，在上外侧软骨和鼻中隔之间的软骨膜下平面形成一个腔隙。基于3D打印技术将聚己内酯制成0.8×0.8厘米的矩形用作鼻植入物。将该材料作为鼻中隔延伸移植物插入并用鼻翼软骨缝合以进行鼻整形。在植入后4周、8周和12周取出植入物，通过大体形态学评估和组织学检查进行评估。
所有病例中植入物的初始形状均未改变，在3个月期间未观察到明确的术后并发症。大体形态学评估证实植入物保持在其初始位置，无移位或挤出。组织学评估显示植入物结构得以维持，有良好的纤维血管长入且炎症反应最小。
聚己内酯可用于隆鼻等鼻重建。聚己内酯易于操作，可避免与自体移植物采集相关的手术时间延长和发病率增加。因此，3D打印设计的PCL植入物未来可作为颅面重建中具有临床生物相容性的材料。
NA。《喉镜》，2017年，第127卷，第1036 - 1043页。
