State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China.
Nanoscale. 2017 Feb 16;9(7):2479-2491. doi: 10.1039/c7nr00033b.
Developing multifunctional nanoparticle-based theranostic systems for personalized cancer diagnosis and treatment is highly desirable. Herein, a magnetic targeting theranostic nanocapsule (NC-SPIOs-IR820-PTX) was fabricated by hierarchically assembling superparamagnetic iron oxide nanoparticles (SPIOs), cyanine dye (IR820) and chemotherapeutic compound of paclitaxel (PTX) with poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA). The nanocapsules exhibited high stability and biocompatibility both in vitro and in vivo. The nanocomposites maintained their morphology in the cellular uptake and showed efficient tumoricidal activity. Most importantly, the external magnetic field could remotely control the nanocapsules and guide them to target tumors for magnetic resonance imaging (MRI)/near-infrared (NIR) fluorescence imaging. The synergistic therapeutic effects of NC-SPIOs-IR820-PTX with extra-magnetic field-induced tumor targeting ability have enhanced the co-therapy of photo-chemotherapy, resulting in significant tumor inhibition effects. Therefore, NC-SPIOs-IR820-PTX theranostics could be applied for magnetic field guided tumor targeting as well as multimodal MRI/NIR imaging, and imaging-guided combined therapy.
开发用于个性化癌症诊断和治疗的多功能基于纳米粒子的治疗诊断系统是非常需要的。在此，通过分级组装超顺磁性氧化铁纳米粒子（SPIOs）、菁染料（IR820）和化疗药物紫杉醇（PTX），制备了磁性靶向治疗纳米胶囊（NC-SPIOs-IR820-PTX）聚（ε-己内酯-共-丙交酯）-b-聚（乙二醇）-b-聚（ε-己内酯-共-丙交酯）（PCLA-PEG-PCLA）。纳米胶囊在体外和体内均表现出高稳定性和生物相容性。纳米复合材料在细胞摄取过程中保持其形态，并表现出高效的杀肿瘤活性。最重要的是，外部磁场可以远程控制纳米胶囊，并引导它们靶向肿瘤进行磁共振成像（MRI）/近红外（NIR）荧光成像。NC-SPIOs-IR820-PTX 与外加磁场诱导的肿瘤靶向能力的协同治疗效果增强了光化疗的联合治疗，导致显著的肿瘤抑制效果。因此，NC-SPIOs-IR820-PTX 治疗诊断系统可用于磁场引导的肿瘤靶向以及多模态 MRI/NIR 成像和成像引导的联合治疗。
