Zhou Huige, Hou Xiaoyang, Liu Ying, Zhao Tianming, Shang Qiuyu, Tang Jinglong, Liu Jing, Wang Yuqing, Wu Qiuchi, Luo Zehao, Wang Hui, Chen Chunying
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
School of Material Science and Engineering, University of Science and Technology Beijing , Beijing 100083, P.R. China.
ACS Appl Mater Interfaces. 2016 Feb;8(7):4424-33. doi: 10.1021/acsami.5b11308. Epub 2016 Feb 10.
Near-infrared (NIR) dyes functionalized magnetic nanoparticles (MNPs) have been widely applied in magnetic resonance imaging (MRI), NIR fluorescence imaging, drug delivery, and magnetic hyperthermia. However, the stability of MNPs and NIR dyes in water is a key problem to be solved for long-term application. In this study, a kind of superstable iron oxide nanoparticles was synthesized by a facile way, which can be used as T1 and T2 weighted MRI contrast agent. IR820 was grafted onto the surface of nanoparticles by 6-amino hexanoic acid to form IR820-CSQ-Fe conjugates. Attached IR820 showed increased stability in water at least for three months and an enhanced ability of singlet oxygen production of almost double that of free dyes, which will improve its efficiency for photodynamic therapy. Meanwhile, the multispectral optoacoustic tomography (MSOT) and NIR imaging ability of IR820-CSQ-Fe will greatly increase the accuracy of disease detection. All of these features will broaden the application of this material as a multimodal theranostic platform.
近红外（NIR）染料功能化磁性纳米颗粒（MNPs）已广泛应用于磁共振成像（MRI）、近红外荧光成像、药物递送和磁热疗。然而，MNPs和近红外染料在水中的稳定性是长期应用需要解决的关键问题。在本研究中，通过一种简便的方法合成了一种超稳定的氧化铁纳米颗粒，其可作为T1和T2加权MRI造影剂。通过6-氨基己酸将IR820接枝到纳米颗粒表面，形成IR820-CSQ-Fe共轭物。附着的IR820在水中至少三个月内显示出更高的稳定性，并且单线态氧产生能力增强，几乎是游离染料的两倍，这将提高其光动力治疗效率。同时，IR820-CSQ-Fe的多光谱光声断层扫描（MSOT）和近红外成像能力将大大提高疾病检测的准确性。所有这些特性将拓宽这种材料作为多模态诊疗平台的应用。
