Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Centre for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Cancer Lett. 2017 Apr 1;390:168-175. doi: 10.1016/j.canlet.2016.12.026. Epub 2016 Dec 29.
Theranostics based on nanoparticles have developed rapidly in the past decade and have been widely used in the diagnosis and treatment of liver cancer, breast cancer, and other tumors. However, for skin cancers, there are limited studies. In the present study, we successfully synthesized a theranostic nanoparticle by grating IR820 onto the surface of chitosan-coated magnetic iron oxide, IR820-CS-FeO, showing an excellent magnetic resonance imaging (MRI) capability and cytotoxic effects against melanoma under irradiation with a near-infrared (NIR) laser (808 nm) in vitro. Furthermore, good stability for up to 8 days and negligible cytotoxicity were observed. These characteristics are important for biomedical applications of nanoparticles. In conclusion, we provide a novel and potential theranostic platform for melanoma treatment and detection.
基于纳米粒子的治疗学在过去十年中发展迅速，并已广泛应用于肝癌、乳腺癌和其他肿瘤的诊断和治疗。然而，对于皮肤癌，相关研究有限。在本研究中，我们成功地将 IR820 接枝到壳聚糖包覆的磁性氧化铁表面，合成了一种治疗学纳米粒子，即 IR820-CS-FeO，其表现出优异的磁共振成像（MRI）能力，并且在近红外（NIR）激光（808nm）照射下对黑色素瘤具有细胞毒性作用，在体外。此外，观察到长达 8 天的良好稳定性和可忽略不计的细胞毒性。这些特性对纳米粒子的生物医学应用很重要。总之，我们为黑色素瘤的治疗和检测提供了一种新颖且有潜力的治疗学平台。
