Harris Ashley D, Saleh Muhammad G, Edden Richard A E
Department of Radiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
Child and Adolescent Imaging Research (CAIR) Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T3B 6A9, Canada.
Magn Reson Med. 2017 Apr;77(4):1377-1389. doi: 10.1002/mrm.26619. Epub 2017 Feb 2.
The Proton magnetic resonance ( H-MRS) spectrum contains information about the concentration of tissue metabolites within a predefined region of interest (a voxel). The conventional spectrum in some cases obscures information about less abundant metabolites due to limited separation and complex splitting of the metabolite peaks. One method to detect these metabolites is to reduce the complexity of the spectrum using editing. This review provides an overview of the one-dimensional editing methods available to interrogate these obscured metabolite peaks. These methods include sequence optimizations, echo-time averaging, J-difference editing methods (single BASING, dual BASING, and MEGA-PRESS), constant-time PRESS, and multiple quantum filtering. It then provides an overview of the brain metabolites whose detection can benefit from one or more of these editing approaches, including ascorbic acid, γ-aminobutyric acid, lactate, aspartate, N-acetyl aspartyl glutamate, 2-hydroxyglutarate, glutathione, glutamate, glycine, and serine. Magn Reson Med 77:1377-1389, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
质子磁共振（H-MRS）波谱包含有关预定义感兴趣区域（体素）内组织代谢物浓度的信息。在某些情况下，由于代谢物峰的分离有限和复杂分裂，传统波谱会掩盖有关含量较少的代谢物的信息。检测这些代谢物的一种方法是使用编辑来降低波谱的复杂性。本综述概述了可用于探究这些被掩盖的代谢物峰的一维编辑方法。这些方法包括序列优化、回波时间平均、J-差异编辑方法（单BASING、双BASING和MEGA-PRESS）、恒定时间PRESS和多量子滤波。然后概述了其检测可受益于这些编辑方法中的一种或多种的脑代谢物，包括抗坏血酸、γ-氨基丁酸、乳酸、天冬氨酸、N-乙酰天冬氨酰谷氨酸、2-羟基戊二酸、谷胱甘肽、谷氨酸、甘氨酸和丝氨酸。《磁共振医学》77:1377 - 1389，2017年。© 2017国际磁共振医学学会。
