二甲双胍-钠-葡萄糖协同转运蛋白2、脱水与酸中毒风险
Metformin-SGLT2, Dehydration, and Acidosis Potential.
作者信息
D'Elia John A, Segal Alissa R, Weinrauch Larry A
机构信息
Kidney and Hypertension Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Department of Pharmacy Practice, MCPHS University, Boston, Massachusetts.
出版信息
J Am Geriatr Soc. 2017 May;65(5):e101-e102. doi: 10.1111/jgs.14724. Epub 2017 Feb 2.
Clinicians are aware of the risks and benefits of metformin in type 2 diabetes. In geriatric populations lactic acidosis due to diminishing kidney function is an issue. The recent addition of a group of agents to control diabetes through increased glycosuria may increase the risk of dehydration and acidosis. This may happen due to gastrointestinal loss from metformin diarrhea or urine loss from diuretics. A typical example is presented.
临床医生了解二甲双胍在2型糖尿病治疗中的风险和益处。在老年人群中，由于肾功能减退导致的乳酸性酸中毒是一个问题。最近添加的一组通过增加糖尿来控制糖尿病的药物可能会增加脱水和酸中毒的风险。这可能是由于二甲双胍引起的腹泻导致胃肠道失水，或利尿剂导致的尿液流失。文中给出了一个典型例子。
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