Yamaguchi Yoshie, Atsumi Takeshi, Poirot Romain, Lee Young-A, Kato Akemi, Goto Yukiori
Primate Research Institute, Kyoto University, 41-2 Kanrin, Inuyama, Aichi, 484-8506, Japan.
Department of Rehabilitation for Brain Functions, Research Institute of Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, 359-8555, Japan.
Psychopharmacology (Berl). 2017 Apr;234(7):1113-1120. doi: 10.1007/s00213-017-4544-6. Epub 2017 Feb 2.
Dopamine (DA) plays a central role in reward processing. Accumulating evidence suggests that social interaction and social stimuli have rewarding properties that activate the DA reward circuits. However, few studies have attempted to investigate how DA is involved in the processing of social stimuli.
In this study, we investigated the effects of pharmacological manipulations of DA D1 and D2 receptors on social vs. nonsocial visual attention preference in macaques.
Japanese macaques were subjected to behavioral tests in which visual attention toward social (monkey faces with and without affective expressions) and nonsocial stimuli was examined, with D1 and D2 antagonist administration.
The macaques exhibited significantly longer durations of gazing toward the images with social cues than did those with nonsocial cues. Both D1 and D2 antagonist administration decreased duration of gazing toward the social images with and without affective valences. In addition, although D1 antagonist administration increased the duration of gazing toward the nonsocial images, D2 antagonism had no effect.
These results suggest that both D1 and D2 receptors may have roles in the processing of social signals but through separate mechanisms.
多巴胺（DA）在奖赏处理中起核心作用。越来越多的证据表明，社交互动和社交刺激具有激活DA奖赏回路的奖赏特性。然而，很少有研究试图探究DA如何参与社交刺激的处理。
在本研究中，我们研究了DA D1和D2受体的药理学操纵对猕猴社交与非社交视觉注意偏好的影响。
对日本猕猴进行行为测试，在给予D1和D2拮抗剂的情况下，检测其对社交刺激（有或没有情感表达的猴脸）和非社交刺激的视觉注意。
猕猴对带有社交线索的图像凝视时间明显长于带有非社交线索的图像。给予D1和D2拮抗剂均减少了对有或没有情感效价的社交图像的凝视时间。此外，虽然给予D1拮抗剂增加了对非社交图像的凝视时间，但给予D2拮抗剂则没有效果。
这些结果表明D1和D2受体可能都在社交信号处理中起作用，但通过不同的机制。
