Department of Food Science and Nutrition, Daegu Catholic University, Gyeongsan, Gyeongbuk, 38430, South Korea.
Ecole Nationale Veterinaire de Toulouse, 31076, Toulouse, France.
Psychopharmacology (Berl). 2018 Apr;235(4):1141-1149. doi: 10.1007/s00213-018-4831-x. Epub 2018 Jan 14.
Dopamine (DA) is a neurotransmitter whose roles have been suggested in various aspects of brain functions. Recent studies in rodents have reported its roles in social function. However, how DA is involved in social information processing in primates has largely remained unclear.
We investigated prefrontal cortical (PFC) activities associated with social vs. nonsocial visual stimulus processing.
Near-infrared spectroscopy (NIRS) was applied to Japanese macaques, along with pharmacological manipulations of DA transmission, while they were gazing at social and nonsocial visual stimuli.
Oxygenated (oxy-Hb) and deoxygenated (deoxy-Hb) hemoglobin changes as well as functional connectivity based on such Hb changes within the PFC network which were distinct between social and nonsocial stimuli were observed. Administration of both D1 and D2 receptor antagonists affected the Hb changes associated with social stimuli, whereas D1, but not D2, receptor antagonist affected the Hb changes associated with nonsocial stimuli.
These results suggest that mesocortical DA transmission in the PFC plays significant roles in social information processing, which involves both D1 and D2 receptor activation, in nonhuman primates. However, D1 and D2 receptor signaling in the PFC mediates different aspects of social vs. nonsocial information processing.
多巴胺（DA）是一种神经递质，其作用已在大脑功能的各个方面得到证实。最近在啮齿动物中的研究报告了其在社交功能中的作用。然而，多巴胺如何参与灵长类动物的社交信息处理在很大程度上仍不清楚。
我们研究了与社交与非社交视觉刺激处理相关的前额叶皮质（PFC）活动。
我们对日本猕猴应用近红外光谱（NIRS），同时对多巴胺传递进行药理学操作，当它们注视社交和非社交视觉刺激时。
在 PFC 网络中观察到了氧合（oxy-Hb）和脱氧（deoxy-Hb）血红蛋白变化以及基于这些 Hb 变化的功能连接，这些变化在社交和非社交刺激之间是不同的。D1 和 D2 受体拮抗剂的给药均影响与社交刺激相关的 Hb 变化，而 D1 但不是 D2 受体拮抗剂影响与非社交刺激相关的 Hb 变化。
这些结果表明，在非人类灵长类动物中，PFC 中的中皮质多巴胺传递在社交信息处理中起着重要作用，涉及 D1 和 D2 受体的激活。然而，PFC 中的 D1 和 D2 受体信号转导介导了社交与非社交信息处理的不同方面。
